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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
ProteomicsPhosphoproteomics sample preparation impacts biological interpretation of signalling responses
Quantitative data-dependent acquisition phosphoproteomics (DDAP) has revolutionised cell signaling studies. However, the impact of the specific DDAP sample preparation method on the phosphoproteome quantified is unclear as each study quantifies only a fraction of the phosphoproteome. Here, we compar...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-25 | PXD025376 | Pride
Phosphoproteomics Tio2 Mouse High-throughput phosphoproteomics Scxphos Sample preparation Highphos Comparative analysis 
MetabolomicsIntegrated Multi-omics Analysis of Human Biliary Organoids Reveals Dysregulated Metabolic and Fibro-Inflammatory Programs in Biliary Atresia
Human intrahepatic biliary organoids were established from liver tissues of children with BA (n = 11), choledochal cysts (CC, n = 5), and histologically normal controls (NC, n = 5). We performed comprehensive multi-omics profiling, including transcriptomics, proteomics, phosphoproteomics, and untarg...
2026-09-02 | MTBLS15528 | MetaboLights
GenomicsIntegration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
Integration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
PRJNA1138715 | ENA
ProteomicsMycobacterium smegtatis phosphoproteomics LC-MS/MS
Protein phosphatase PstP is conserved throughout the Actinobacteria in a genetic locus related to cell wall synthesis and cell division. In many Actinobacteria it is the sole annotated serine threonine protein phosphatase to counter the activity of multiple serine threonine protein kinases. We used ...
ORGANISM(S): Mycolicibacterium smegmatis MKD8 
2019-11-12 | PXD011805 | Pride
Bacterial protein phosphatase Bacterial signal transduction Cell division Actinobacteria Phosphoproteomics Mycobacteria Mycobacterium smegmatis 
ProteomicsFAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids shows Activation of Ferroptotic Death Mechanism
Colorectal cancer (CRC) is projected to become the third most diagnosed and third most fatal cancer in the United States by 2024, with early onset CRC on the rise. Research is constantly underway to discover novel therapeutics for the treatment of various cancers to improve patient outcomes and surv...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050987 | Pride
Phosphoproteomics Mass spectrometry Colorectal cancer Cancer Proteomics Data-independent acquisition Spheroids 
ProteomicsA549 CD38 phosphoproteomics analysis
A549 CD38 overexpression cells phosphoproteomics analysis
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009917 | Pride
Cd38 A549 Phosphoproteomics analysis 
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
GenomicsPhosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
PRJNA627466 | ENA
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