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ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-31 | MSV000085203 | MassIVE
ProteomicsThe use of LysargiNase complementary to trypsin in large scale phosphoproteome study for unambiguous phosphosite localization
Understanding of kinase-guided signaling pathways requires identification and analysis of phosphorylation sites. Mass spectrometry (MS)-based phosphoproteomics is a rapid and highly sensitive approach for high-throughput identification of phosphorylation sites. However, the exact localization of pho...
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD011178 | Pride
Phosphoproteome Phosphosite localization Lysarginase 
ProteomicsDeepFLR Facilitates False Localization Rate Control in Phosphoproteomics
Site-specific phosphorylation events affect nearly all the cellular processes and correct phosphosite localization plays an important role in biological or medical health studies. However, direct false localization rate (FLR) control remains challenging in phosphoproteomics. Here, we propose DeepFLR...
ORGANISM(S): Homo Sapiens 
2023-04-04 | PXD037580 |
ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD007058 | Pride
Mascot/ptmrs Andromeda/ptmscore Orbitrap fusion Mass spectrometry Phosphoproteomics 
UnknownPhosphosite charge rather than shootward localization determines OCTOPUS activity in root protophloem.
Not available
S-EPMC5514738 | biostudies-literature
ProteomicsFunction of the MYND domain and C-terminal region in regulating the subcellular localization and catalytic activity of the SMYD family lysine methyltransferase Set5
SMYD lysine methyltransferases target histones and non-histone proteins for methylation and are critical regulators of muscle developmental and implicated in neoplastic transformation. They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, as well as an ex...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-11 | PXD014756 | Pride
Methyltransferase Saccharomyces cerevisiae 
UnknownDeepFLR facilitates false localization rate control in phosphoproteomics.
Not available
S-EPMC10119288 | biostudies-literature
ProteomicsBenchmarking multiple fragmentation methods on an Orbitrap Fusion for top-down phospho-proteoform characterization
Top-down analysis of intact proteins by mass spectrometry provides an ideal platform for comprehensive proteoform characterization, in particular, for the identification and localization of post-translational modifications (PTM) co-occurring on a protein. One of the main bottlenecks in top-down prot...
ORGANISM(S): Homo sapiens (Human) 
2015-07-16 | PXD001845 | Pride
Fragmentation Bora Ethcd Top down proteomics Phosphorylation Proteoform Orbitrap fusion 
UnknownProtein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.
Not available
S-EPMC1622776 | biostudies-literature
UnknownMining recent brain proteomic databases for ion channel phosphosite nuggets.
Not available
S-EPMC3010060 | biostudies-literature
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