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ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD007058 | Pride
Mascot/ptmrs Andromeda/ptmscore Orbitrap fusion Mass spectrometry Phosphoproteomics 
ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-31 | MSV000085203 | MassIVE
ProteomicsA CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor cells respectively called neuroblasts or sensory organ precursors use PAR polarity during mitosis to control cell f...
ORGANISM(S): Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2024-07-02 | PXD051560 | Pride
Cell polarity Cell cycle Drosophila Asymmetric cell division 
ProteomicsQuantitative consequences of protein carriers in immunopeptidomics and tyrosine phosphorylation MS2 analyses
Evaluating the impact of a carrier proteome on data quality and quantity in multiplexed pTyr and MHC analyses.
ORGANISM(S): Homo sapiens (Human) 
2021-06-01 | PXD025073 | Pride
Mhc Phosphorylation Lc-ms/ms 
ProteomicsA conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress
Mammalian TFEB and TFE3, as well as their ortholog in C. elegans HLH-30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation, oxidative stress and pathogen infection. In this study we identify a novel mechanism of TFEB/HLH-30 regula...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022258 | Pride
Hlh-30 Tfeb Glutathionylation Tfe3 Lysosomes 
ProteomicsCDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock
All vertebrates share a segmented body axis. Segments form from the rostral end of the presomitic mesoderm (PSM) with a periodicity that is regulated by the segmentation clock. The segmentation clock is a molecular oscillator that exhibits dynamic clock gene expression across the PSM with a periodic...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD013038 | Pride
Notch Signalling Cell cycle Fbxw7 Somitogenesis Phosphorylation 
ProteomicsOpposing roles for AMPK in regulating distinct mitophagy pathways
Mitophagy degrades damaged mitochondria, but we show here that it can also target functional mitochondria. This latter scenario occurs during programmed mitophagy and involves the mitophagy receptors NIX and BNIP3. While AMPK, the energy-sensing protein kinase, can influence damaged-induced mitophag...
ORGANISM(S): Homo sapiens (Human) 
2024-11-29 | PXD056956 | Pride
Autophagy Nix Parkin Skeletal muscle Liver Ampk Ulk Mitophagy 
ProteomicsFinding TMEM55B interactors and ubiquitination sites
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD043609 | Pride
Tmem55b ms 
ProteomicsFinding TMEM55B phoshporylation site
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD046394 | Pride
Tmem55b ms 
ProteomicsUnveiling the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model
Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. The current study aims to understand how these variants affect cellular function at the phenotypic ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-01-12 | PXD060549 | Pride
Fly Juvenile granulosa cell tumors Akt1 Ovary 
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