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ProteomicsmPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD073765 | Pride
Mpfc Acetylcholine Major depressive disorder Stress models Learned helplessness Muscarinic receptors Proteomics 
ProteomicsSex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure
Sex differences in behaviors relevant to nicotine addiction have been observed in rodent models and human subjects. Behavioral, imaging and epidemiological studies also suggest underlying sex differences in mesolimbic dopamine signaling pathways. In this study we evaluated the proteome in the ventra...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD023859 | Pride
Sex Nicotine exposure Mouse Vta Nac 
UnknownA translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.
Not available
S-EPMC4376109 | biostudies-literature
UnknownSpecification of claustro-amygdalar and palaeocortical neurons and circuits.
Not available
S-EPMC11821539 | biostudies-literature
UnknownDistributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research.
Not available
S-EPMC7965796 | biostudies-literature
UnknownA multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder.
Not available
S-EPMC12042318 | biostudies-literature
UnknownDemographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?
Not available
S-EPMC11929602 | biostudies-literature
UnknownDeleterious coding variation associated with autism is consistent across populations, as exemplified by admixed Latin American populations.
Not available
S-EPMC11741445 | biostudies-literature
UnknownAssociation of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis.
Not available
S-EPMC11393401 | biostudies-literature
UnknownLatent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.
Not available
S-EPMC10524438 | biostudies-literature
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