Sort   by:  
 Page size 
ProteomicsThe pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD017508 | Pride
Sirtuins Leukemia Human Mitochondria Orbitrap q-exactive 
ProteomicsMembrane proteome profile of MSI-tumor organoids exposed to conditioned media of MSI and MSS-tumor organoids
MSI-tumor organoids were previously stimulated with 200 ng/mL IFNγ for 24 hours. Then, organoids were dissociated into single cells using TrypLE express and resuspended in conditioned media. Cells were seeded in a 24-well plate and incubated for 24 hours at 37°C. After incubation, tumor cells were c...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD066343 | Pride
Protein signature. Mass spectrometry (ms) Msi-tumor organoids Membrane proteomics 
ProteomicsPathological deficit of Cystatin B impairs synaptic plasticity in EPM1 human cerebral organoids
Cystatin B (CSTB) is a small protease inhibitor involved in cell proliferation and migration, and composition of extracellular matrix during brain development. Loss-of-function mutations in the gene encoding CSTB cause progressive myoclonic epilepsy 1 (EPM1). We previously demonstrated that CSTB is ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041125 | Pride
Epm1  cystatin b  synaptic plasticity 
ProteomicsCystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy
Progressive myoclonus epilepsy (PME) of Unverricht-Lundborg-type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide. Mutations in the gene encoding cystatin B (CSTB) are the primary genetic cause of EPM1. Here, we investigate the role of CSTB duri...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD018021 | Pride
Cystatin b  human cerebral organoids  progressive myoclonus epilepsy  mass spectrometry 
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
ProteomicsHuman Histone Fragments Display Antibacterial Properties against Pseudomonas aeruginosa
Differential proteomic experiment using Pseudomonas aeruginosa in the presence and the absence of Human Histone Fragments.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-09-14 | PXD080063 | Pride
Human histones Antibacterial activity H1.2 peptide Neutrophil extracellular traps (nets) Outer membrane biogenesis Immunomodulatory effects Antimicrobial peptides (amps) Pseudomonas aeruginosa 
TranscriptomicsResistant response of leaves of upland cotton line Im216 to Xanthomonas campestris pv. malvacearum race 1
Gene expression profiling of upland cotton line Im216 to inoculation with Xanthomonas campestris pv. malvacearum race 1. Fifth or sixth leaves of the bacterial blight-resistant cotton line Im216, which had been grown in a plant growth chamber, were infiltrated with a suspension of about 5x10^6 colon...
ORGANISM(S): Gossypium hirsutum 
2010-07-01 | E-GEOD-2851 | biostudies-arrayexpress
ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
ProteomicsProteomics reveals PFOS-induced alteration of lipid utilization and xenobiotic metabolism in a model of PFOS-augmented diet-induced fatty liver
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has been used for the last 60+ years in numerous industrial and commercial applications. In mice, PFOS administration is known to induce hepatomegaly and hepatic steatosis. The aim of the present study was to evalua...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-30 | PXD016161 | Pride
Perfluorinated compounds Pfos Proteomics Liver High fat diet Weight loss Nafld 
ProteomicsStable isotope probing with 13C-labeled bicarbonate/proteomics of cyanobacterial consortium collected from photobioreactors enriched from soda lake microbial mats in BC, Canada
In this work we used stable isotope probing/proteomics to study uptake of carbon sources by members of the cyanobacterial consortium. The database for protein identification was obtained from assembled metagenomes.
ORGANISM(S): Phormidium sp. OSCR 
2022-01-21 | PXD028578 | Pride
Heterotrophs Stable isotope probing Cyanobacteria 
Sort   by:  
 Page size