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GenomicsPIM447 treatment in T-ALL PDX splenocytes
PIM447 treatment in T-ALL PDX splenocytes
PRJNA606962 | ENA
GenomicsEffect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P
Effect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P
PRJNA1109296 | ENA
TranscriptomicsPIM447 treatment in T-ALL PDX splenocytes
A subset of T-ALL/T-LBL patients is characterized by overexpression of the oncogenic Serine/Threonine kinase PIM1. Mechanisms for PIM1 overexpression are translocations involving the TCRb and PIM1 loci, JAK/STAT activating mutations and responsiveness to cytokinens in the tumor microenvironment, suc...
ORGANISM(S): Homo sapiens 
2020-02-17 | GSE145165 | GEO
TranscriptomicsEffect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P
To test whether the activity of PIM proteins promotes an aberrant activation of the molecular cascades that are essential for the leukemogenic effects mediated by JAK/STAT pathway mutations, we analyzed RNA-seq data from M07e cells expressing JAK3Q988P that were treated with PIM447 or left untreated...
ORGANISM(S): Homo sapiens 
2024-07-15 | GSE266986 | GEO
UnknownControl of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.
Not available
S-EPMC5325370 | biostudies-literature
UnknownProtein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma.
Not available
S-EPMC7598606 | biostudies-literature
UnknownInsights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study.
Not available
S-EPMC6862308 | biostudies-literature
GenomicsInhibition of protein translation is a major mechanism for the activity of the pan-PIM kinase inhibitor PIM447 in combination with Pomalidomide-dexamethasone in multiple myeloma
Inhibition of protein translation is a major mechanism for the activity of the pan-PIM kinase inhibitor PIM447 in combination with Pomalidomide-dexamethasone in multiple myeloma
PRJNA575866 | ENA
TranscriptomicsInhibition of protein translation is a major mechanism for the activity of the pan-PIM kinase inhibitor PIM447 in combination with Pomalidomide-dexamethasone in multiple myeloma
The overexpression of PIM kinases in hematologic malignancies, including multiple myeloma, make PIM inhibitors an attractive therapeutic strategy for these diseases. Recent preclinical data from our group demonstrated the anti-myeloma effect of the pan-PIM kinase inhibitor PIM447, along with its syn...
ORGANISM(S): Homo sapiens 
2020-11-02 | GSE138440 | GEO
ProteomicsWhole Proteomics of 24 hr pan Pim kinase inhibitor treatment of IL2 cultured CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051214 | Pride
Lc-msms Pim447 Azd1208 Tofacitinib Mouse Pim1 Pim2 Cd8 t cell Cytotoxic t lymphocyte Pim kinase 
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