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ProteomicsObesity significantly alters the human sperm proteome, with implications for fertility
While obesity has links to poor semen parameters and reduced fertility, the causative links between obesity and male infertility are unclear, particularly on a molecular level. We investigated how obesity impacts the human sperm proteome, to further understand any implications for fertility. Sperm p...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD014849 | Pride
Human Obesity Sperm Lfq Lc-ms/ms 
ProteomicsQuantitative proteomic analysis of seminal plasma, sperm membrane proteins and seminal extracellular vesicles suggests vesicular mechanisms aid in the removal and addition of proteins to the ram sperm membrane.
Quantitative proteomic studies are contributing greatly to our understanding of the spermatozoon through the provision of detailed information on the proteins spermatozoa acquire and shed in the acquisition of fertility. Extracellular vesicles (EVs) are thought to aid in the delivery of proteins to ...
ORGANISM(S): Ovis aries 
2020-05-08 | PXD017537 | Pride
Prostasomes Microvesicles Edil3 Epididysomes Sperm surface 
ProteomicsCryopreservation and egg yolk medium alter the proteome of ram spermatozoa
Cryopreservation causes significant lethal and sub-lethal damage to spermatozoa. In order to improve freezing outcomes, a comprehensive understanding of sub-lethal damage is required. Cryopreservation induced changes to sperm proteins have been investigated in several species, but few have employed ...
ORGANISM(S): Ovis aries 
2018-04-26 | PXD009331 | Pride
Swath Sperm Ram 
ProteomicsDynamic sperm proteome remodelling during epididymal maturation in a marsupial, Macropus giganteus
While assisted reproductive technologies (ARTs) are widely used in domestic animals, successful implementation of ARTs to conserve wildlife species remains challenging. In macropods, crucial aspects of fundamental reproductive biology, including changes induced by epididymal maturation, remain unkno...
ORGANISM(S): Macropus giganteus 
2025-09-29 | PXD064577 | Pride
Epididymal Sperm Kangaroo Marsupial Macropod Epididymis Spermatozoa 
ProteomicsThe Koala (Phascolarctos cinereus) Prostate: A Proteomic Perspective on Gland Segmentation
Australia’s most iconic animal, the koala (Phascolarctos cinereus), faces significant population decline from habitat loss, disease, and environmental pressures. Conservation has focused on assisted breeding technology and reproductive pathologies, yet koala reproductive biology remains poorly under...
ORGANISM(S): Phascolarctos cinereus (Koala) 
2026-01-23 | PXD067256 | Pride
Koala Proteomics Prostate 
ProteomicsComparative analysis of progesterone secretion and plasma proteome across the pregnant and non-pregnant luteal phase of the koala (Phascolarctos cinereus)
Differences in the reproductive physiology of pregnant and mated non-pregnant koalas were examined to investigate maternal recognition and identify potential circulating pregnancy and/or embryonic loss biomarkers. Koalas were separated into three groups: pregnant (n = 4), mated but non-parturient (n...
ORGANISM(S): Phascolarctos cinereus (Koala) 
2026-08-13 | PXD079795 | Pride
Progesterone  plasma proteome  maternal recognition of pregnancy  marsupial 
UnknownNew and Interesting Fungi. 3.
Not available
S-EPMC7452156 | biostudies-literature
UnknownEfficacy of baricitinib in patients with moderate-to-severe rheumatoid arthritis up to 6.5 years of treatment: results of a long-term study.
Not available
S-EPMC11443035 | biostudies-literature
UnknownAnastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial.
Not available
S-EPMC4769326 | biostudies-literature
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