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ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
2021-04-25 | PXD023893 | panorama
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. ...
2024-09-02 | BIOMD0000000644 | BioModels
ProteomicsEndothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy
The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular...
ORGANISM(S): Homo sapiens (Human) 
2019-10-04 | PXD012975 | Pride
Autophagy Pka Atg16l1 
MetabolomicsEnterotoxigenic Bacteroides fragilis exacerbates alcoholic liver disease progression through kynurenine mediated AMPK signaling inhibition and retinoic acid depletion

Abstract Background & Aims: Alcoholic liver disease (ALD) pathogenesis involves gut microbiota dysbiosis, but specific pathobionts and mechanisms remain unclear. This study investigated the role of patient-derived enterotoxigenic Bacteroides fragilis (ETBF) in ALD progression and its underlyi...

2026-09-07 | MTBLS15572 | MetaboLights
TranscriptomicsInhibition of Peripheral Serotonin Activates Hepatic AMPK and Reduces Monocyte-Derived Liver Macrophages, Ameliorating Obesity-Associated Fibrosis
Monocyte-derived liver macrophages are critical in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, but their recruitment mechanisms remain unclear. Serotonin (5-hydroxytryptamine, 5HT) is a conserved monoamine synthesized by tryptophan hydroxylase (Tph...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15760 | biostudies-arrayexpress
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 and dominant negative effect
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 and dominant negative effect This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein pho...
2024-09-02 | BIOMD0000000645 | BioModels
GenomicsProtein Kinase A (PKA) inhibition in Saccharomyces cerevisiae and Kluyveromyces lactis
Protein Kinase A (PKA) inhibition in Saccharomyces cerevisiae and Kluyveromyces lactis
PRJNA687401 | ENA
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Musante V, Li L, Kanyo ...
2024-09-02 | BIOMD0000000643 | BioModels
ProteomicsPRM of Nth1 phospho-peptides in response to AGC-kinase inhibition
Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take centre stage in regulating this process in S. cerevisiae. To understand how these kinases co-ordinately regulate cellular functions we compared the phospho-proteome of ex...
ORGANISM(S): Saccharomyces Cerevisiae 
2020-03-22 | PXD015760 | panorama
ProteomicsCross-talk between PKA and PKG controls pH-dependent host cell egress of Toxoplasma gondii
Toxoplasma gondii encodes three Protein Kinase A catalytic (PKAc1-3) and one regulatory (PKAr) subunits to integrate cAMP-dependent signals. Here, we show that inactive PKAc1 is maintained at the parasite pellicle by interacting with dually acylated PKAr. Either a conditional knockdown of PKAr or th...
ORGANISM(S): Toxoplasma gondii Toxoplasma gondii 
2017-10-12 | PXD006045 | Pride
Imac T. gondii Phospho Lc-msms 
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