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ProteomicsPhosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55
Protein phosphatase regulatory subunits are increasingly recognized as promising drug targets. In the absence of an existing drug, inducible degradation provides a means of predicting candidate targets. We here employed auxin-inducible degradation of S. cerevisiae PP2A regulatory subunit Cdc55 in co...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-10-15 | PXD019481 | Pride
Degron Protein phosphatase Silac Pp2a Phosphoproteomics Lc-msms 
ProteomicsPhosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55
Protein phosphatase regulatory subunits are increasingly recognized as promising drug targets. In the absence of an existing drug, inducible degradation provides a means of predicting candidate targets. We here employed auxin-inducible degradation of S. cerevisiae PP2A regulatory subunit Cdc55 in co...
ORGANISM(S): Saccharomyces Cerevisiae 
2021-01-27 | PXD019534 | panorama
Proteomicsglc and 1-NM-PP1 timecourses in tpk1/2/3as; TMT2 (4646)
Samples taken at different timepoints after glucose addition. Strain ACY142. Different timepoints after 1-NM-PP1; for model building
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD036029 | Pride
Glucose Yeast 
ProteomicsYeast AGC-kinases phospho-proteomics
Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take centre stage in regulating this process in S. cerevisiae. To understand how these kinases co-ordinately regulate cellular functions we compared the phospho-proteome of ex...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-27 | PXD015668 | Pride
Ypk1 Chemical genetics Agc-kinases Pka Sch9 S. cerevisiae 
ProteomicsPRM of Nth1 phospho-peptides in response to AGC-kinase inhibition
Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take centre stage in regulating this process in S. cerevisiae. To understand how these kinases co-ordinately regulate cellular functions we compared the phospho-proteome of ex...
ORGANISM(S): Saccharomyces Cerevisiae 
2020-03-22 | PXD015760 | panorama
ProteomicsThe Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast
Naturally occurring and drug-induced DNA-protein crosslinks (DPCs) interfere with key DNA transactions if not timely repaired. The unique family of DPC-specific proteases Wss1/SPRTN targets DPC protein moieties for degradation, including topoisomerase-1 trapped in covalent crosslinks (Top1ccs). Here...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-22 | PXD016376 | Pride
Lc-msms Crosslink repair S.cerevisiae Silac Ddi1 
OtherHuntingtin associated protein (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP), specific for the cGMP-dependent protein kinase Iβ isoform.
Data from ProteomeXchange, PXD ID: PXD001434. Published as part of J Biol Chem. 2015 Feb 4. pii . From the Abstract: {{i}} ... Here, we extend on this cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary in...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320007631 | GPMDB
Resource Reanalysis 
UnknownIn situ cryo-ET dataset of Chlamydomonas reinhardtii prepared using cryo-plasmaFIB milling
Not available
EMPIAR-11830 | biostudies-other
UnknownNon-obstructive high-risk plaques increase the risk of future culprit lesions comparable to obstructive plaques without high-risk features: the ICONIC study.
Not available
S-EPMC7440964 | biostudies-literature
UnknownAge- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study.
Not available
S-EPMC8218779 | biostudies-literature
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