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TranscriptomicsArchitecture of the RNA polymerase II-Mediator core transcription initiation complex
Comparative Dynamic Transcriptome Analysis (cDTA) enables global analysis of newly synthesized RNA as described in Sun et al. Genome Res. 2012 (DOI:10.1101/gr.130161.111) and reveals defects in transcription with much higher sensitivity than conventional steady-state methods. cDTA was carried out a...
ORGANISM(S): Saccharomyces cerevisiae S288c 
2015-02-04 | E-MTAB-2942 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of terminating spliceosomes
In this project, we investigated how the spliceosome bound to an excised intron-lariat is remodeled and how the associated intron-lariat is debranched during the process collectively known as spliceosome termination. We used a native pulldown from a C. elegans strain carrying an endogenous tag on th...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-08-19 | PXD081218 | Pride
Human Yju2b Cwf19l1 Leng1 C. elegans Hek293t cells K562 cells Dhx35 Spliceosome Prp19 Dbr1 
UnknownCryo electron tomography dataset of purified human TREX-mRNPs
Not available
EMPIAR-11465 | biostudies-other
UnknownStructure of an ALYREF-exon junction complex hexamer
Not available
EMPIAR-12036 | biostudies-other
UnknownCryo-EM dataset of human UAP56–LENG8–PCID2–SEM1 complex in the presence of 15U RNA and ATP
Not available
EMPIAR-13982 | biostudies-other
UnknownCryo-EM dataset of human UAP56–TREX-2 complex in the presence of 15U RNA and AMP-PNP
Not available
EMPIAR-13983 | biostudies-other
UnknownCryo-EM dataset of human UAP56–LENG8–PCID2–SEM1 complex in the presence of 15U RNA and AMP-PNP
Not available
EMPIAR-13984 | biostudies-other
ProteomicsAn ATP-gated molecular switch orchestrates human messenger RNA export
The nuclear export of messenger RNA (mRNA) is an important step in eukaryotic gene expression. Despite recent molecular insights into how newly transcribed mRNAs are packaged into ribonucleoprotein complexes (mRNPs), the subsequent events that govern mRNA export are poorly understood. Here, we uncov...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD069399 | Pride
Tho Trex-2 Uap56 Gene expression Mrna export 
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