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TranscriptomicsBCL6 ChIP on chip using a Nimblegen custom tiling array
To determine whether BCL6 binds to the certain locus we performed genomic localization studies by chromatin immunoprecipitations (ChIP) using a densely tiled custom oligonucleotide microarray covering the genomic loci of different genes. Keywords: ChIP-chip, Transcription Factor localization The ex...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-7673 | biostudies-arrayexpress
TranscriptomicsExpressoin data from iPSC with different cell of origin
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. We use expresson profiling to determine differn...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22043 | biostudies-arrayexpress
TranscriptomicsCell of origin influences molecular and functional properties of murine induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here, we show that iPSCs obtained from fibrobla...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22827 | biostudies-arrayexpress
ProteomicsTINC - a method to dissect transcriptional complexes at single locus resolution - reveals novel Nanog regulators in mouse embryonic stem cells
Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gene expression. Advances in genome-wide epigenome profiling techniques have significantly increased our understanding of cell-specific utilization of REs. However, it remai...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-14 | PXD022088 | Pride
Nanog Cellular identity Stem cells Regulatory elements Tinc 
TranscriptomicsDefining a molecular roadmap of cellular reprogramming into iPS Cells [DNA methylation]
Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcri...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-45248 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsEarly passage mouse induced pluripotent stem (iPS) cells derivated from various somatic cell origins
Induced pluripotent stem (iPS) cells have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPS cells generated from different cell types are molecularly and functionally similar. Here, we show that iPS cells obtained from fi...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22908 | biostudies-arrayexpress
TranscriptomicsIncomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic comparison of human iPS cells generated from hepatocytes (representative of endoderm), skin fi...
ORGANISM(S): Homo sapiens 
2011-04-17 | E-GEOD-23034 | biostudies-arrayexpress
GenomicsDefining a molecular roadmap of cellular reprogramming into iPS cells [ChIP-Seq]
Factor induced reprogramming is a slow and inefficient process with only rare cells progressing towards induced pluripotent stem cells (iPSCs). Owing to these restraints, mechanistic studies have been limited to analyses of heterogeneous bulk populations undergoing reprogramming and partially reprog...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-42477 | biostudies-arrayexpress
UnknownSoluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients.
Not available
S-EPMC10455097 | biostudies-literature
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