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ProteomicsKv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization
Polygenic scores (PGS) capture the combined effect of many common genetic variants on quantitative traits and disease risk, yet their functional consequences at the protein level remain poorly defined. Here, we integrated quantitative and interaction proteomics to resolve how polygenic liability for...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD077616 | Pride
Polygenic scores Herg Cardiomyocytes Arrhythmia Kv11.1 Human induced pluripotent stem cells 
GenomicsEvaluation of polygenic risk scores for hormones and receptors levels in patients with vestibulodynia: a case-control study
Evaluation of polygenic risk scores for hormones and receptors levels in patients with vestibulodynia: a case-control study
PRJEB75751 | ENA
GenomicsLow-pass sequencing increases the power of GWAS and decreases measurement error of polygenic risk scores compared to genotyping arrays
Low-pass sequencing increases the power of GWAS and decreases measurement error of polygenic risk scores compared to genotyping arrays
PRJNA698238 | ENA
GenomicsLow-pass sequencing increases the power of GWAS and decreases measurement error of polygenic risk scores compared to genotyping arrays
Low-pass sequencing (sequencing a genome to an average depth less than 1× coverage) combined with genotype imputation has been proposed as an alternative to genotyping arrays for trait mapping and calculation of polygenic scores. To empirically assess the relative performance of these technologies f...
ORGANISM(S): Homo sapiens 
2021-01-31 | GSE165845 | GEO
UnknownPolygenic Scores and Networks of Psychopathology Symptoms.
Not available
S-EPMC11170456 | biostudies-literature
TranscriptomicsBRBseq of human skin-derived precursor hepatic progenitor-like cells with varying polygenic risk score for hepatic fat content exposed in vitro to vehicle-matched control medium or triggers related to MASH
92 human skin-derived precursor (hSKP) cell lines, isolated from unique donors, were genotyped for the following SNPs that have been linked to metabolic dysfunction-associated steatotic liver disease (MASLD) onset and progression: PNPLA3 rs738409 C>G, TM6SF2 rs58542926 C>T, GCKR rs1260326 C>T and MB...
ORGANISM(S): Homo sapiens 
2026-07-20 | E-MTAB-15891 | biostudies-arrayexpress
UnknownPolygenic scores contribution to Parkinson's disease comorbidities.
Not available
S-EPMC12448616 | biostudies-literature
UnknownThe Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores.
Not available
S-EPMC9438378 | biostudies-literature
UnknownPolygenic resilience scores capture protective genetic effects for Alzheimer's disease.
Not available
S-EPMC9314356 | biostudies-literature
UnknownPolygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.
Not available
S-EPMC8759285 | biostudies-literature
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