Sort   by:  
 Page size 
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD062134 | Pride
Acrolein-icl Fa pathway Acetaldehyde-icl Polymerase kappa Translesion synthesis 
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD066315 | Pride
Dna polymerase kappa Acrolein-icl Translesion synthesis Fanconi anemia pathway Acetaldehyde-icl 
TranscriptomicsTranscription profiling of rat pancreatic beta-cells in response to cytokine exposure and NF-kappa B activation blocking
Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic beta-cells. Based on findings suggesting NF-kappa B plays a role in beta cell apoptosis, we blocked NF-kappa B activation in cytokine-exposed FACS sorted beta cells by a recombinant adenovirus (AdI kappa B((SA)2)) containi...
ORGANISM(S): Rattus norvegicus 
2006-06-16 | E-CBIL-9 | biostudies-arrayexpress
ProteomicsCatalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase kappa (PolK) has the distinctive ability to bypass minor groove DNA adduct...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-27 | PXD044258 | Pride
Xenopus Tls Polz Polk Rev1 Polymerase kappa Ubiquitin Translesion dna synthesis Pcna Dna replication 
GenomicsActivity of DNA polymerase kappa across the genome in human fibroblasts
Activity of DNA polymerase kappa across the genome in human fibroblasts
PRJNA1081783 | ENA
TranscriptomicsIFN-kappa inhibits HPV31 transcription by inducing Sp100 proteins
Using doxycycline-inducible IFN-kappa expression in CIN612-9E cells, which maintain extrachromosomally replicating HPV31 genomes, we demonstrate that IFN-kappa inhibits the growth of these cells and reduces viral transcription and replication. Interestingly, the initiation of viral early transcripti...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74658 | biostudies-arrayexpress
UnknownMammalian DNA Polymerase Kappa Activity and Specificity.
Not available
S-EPMC6695781 | biostudies-literature
OtherActivity of DNA polymerase kappa across the genome in human fibroblasts
DNA polymerase kappa (PolK) is a specialized polymerase that has multiple cellular roles such as translesion DNA synthesis, replicating repetitive sequences, and nucleotide excision repair. We have developed a method for capturing DNA synthesized by PolK utilizing a PolK - specific substrate, N2-(4-...
ORGANISM(S): Homo sapiens 
2024-06-17 | GSE260451 | GEO
UnknownBeyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability.
Not available
S-EPMC3287198 | biostudies-literature
GenomicsPoised RNA Polymerase II changes over developmental time and prepares genes for future expression (MNase-seq data)
Poised RNA polymerase II is predominantly found at developmental control genes and is thought to allow their rapid and synchronous induction in response to extracellular signals. How the recruitment of poised RNA Pol II is regulated during development is not known. By isolating muscle tissue from Dr...
ORGANISM(S): Drosophila melanogaster 
2012-12-20 | E-GEOD-34283 | biostudies-arrayexpress
Sort   by:  
 Page size