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ProteomicsFGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Mitochondrial integrated stress response emerged as a major adaptive pathway to respiratory chain deficiency, but tissue-specifics of its regulation or how it adapts to different levels of mitochondrial dysfunction are largely unknown. Here we report that diverse levels of mitochondrial cardiomyopat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-27 | PXD031324 | Pride
Mitochondria Fgf21 Oxphos Cardiomyopathy Clpp 
Proteomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Mitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings of this regulation and the complete spectrum of these physiological outcomes remain largely u...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD064288 | Pride
Nuclear softening Brown adipose tissue Mitochondria 2-hydroxyglutarate 
ProteomicsSingle-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes
Single-cell proteomics analysis of human oocytes from both young and old women
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-15 | MSV000093870 | MassIVE
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