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ProteomicsB-cell-specific MYD88 L252P expression causes a premalignant gammopathy resembling IgM MGUS
A highly recurrent, somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-kB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here we introduced an inducible leucine to...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-06 | PXD017292 | Pride
Lymphoid neoplasia 
ProteomicsProteomics of serotonergic autoregulation
Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055579 | Pride
Serotonin Serotonin transporter Brain Tryptophan hydroxylase Autoregulation Mouse 
UnknownNeurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic.
Not available
S-EPMC9996880 | biostudies-literature
UnknownTransition to a Moist Greenhouse with CO2 and solar forcing.
Not available
S-EPMC4748134 | biostudies-literature
UnknownPhenotype-tissue expression and exploration (PTEE) resource facilitates the choice of tissue for RNA-seq-based clinical genetics studies.
Not available
S-EPMC8573933 | biostudies-literature
ProteomicsNeurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
We previously discovered a sex-by-genotype defect in microglia function using a germline heterozygous knockout mouse model of Neurofibromatosis type 1 (Nf1+/- mice), in which only microglia from male Nf1+/- mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic ap...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035881 | Pride
Purinergic signaling Sex differences Neurofibromin Nf1 Cortex Microglia Genetically engineered mice 
UnknownA regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling.
Not available
S-EPMC11466655 | biostudies-literature
ProteomicsUSP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
To decipher the role of USP15 in DNA damage in leukemia cells, endogenous USP15 was immunoprecipitated from MV4-11 and Kasumi-1 cell lines under naive and DNA stress conditions (Mitomycin C, 30nM, 1h). 355 candidates co-immunoprecipitated with USP15 in all the conditions, in 4 independent experiment...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD020612 | Pride
Human Dna damage Ubiquitin 
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
UnknownMicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR.
Not available
S-EPMC4891129 | biostudies-literature
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