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TranscriptomicsPulmonary alveolar macrophages (PAMs) of Tongcheng piglets response to HP-PRRSV infection in vivo
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is the most economically important disease in pig populations. Lung damage is one major pathological condition following PRRSV infection, often leading to animal death. In vivo, PRRSV productive infection occurs pred...
ORGANISM(S): Sus scrofa 
2012-06-30 | E-GEOD-22782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig alveolar macrophages infected with Porcine Respiratory Reproductive Syndrome Virus
A primary culture of Porcine Alveolar Macrophages (PAM) from six animals was split in two: one was infected at a multiplicity of infection (MOI) of 10 with a 13th passage of PRRSV Lelystad virus. The other culture was maintained as control. The percentage of infected cells ranged between 60 and 70% ...
ORGANISM(S): Sus scrofa 
2008-07-01 | E-MEXP-1350 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of porcine alveolar macrophages in response to Streptococcus suis serotype 2
Incubation of porcine alveolar macrophages with two different strains of streptococcus suis and a control
ORGANISM(S): Sus scrofa 
2008-08-19 | E-MEXP-1756 | biostudies-arrayexpress
TranscriptomicsThe porcine microRNA transcriptome response to porcine cytomegalovirus infection
Porcine cytomegalovirus (PCMV; genus Cytomegalovirus, subfamily Betaherpesvirinae, family Herpesviridae) is an immunosuppressive virus that mainly inhibits the immune function of T lymphocytes and macrophages, which has caused great distress to the farming industry. In this study, we obtained the mi...
ORGANISM(S): Sus scrofa 
2015-12-19 | E-GEOD-76156 | biostudies-arrayexpress
ProteomicsProteomic and bioinformatic characterization of extracellular vesicles released from human primary macrophages upon influenza A infection
We have previously shown that IAV infection of human monocyte-derived macrophages causes major alterations to subcellular protein trafficking inside the cell and triggers robust protein secretion (Lietzén et al, 2011). Here, we have used high-throughput proteomics to identify proteins secreted in ex...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080643 | MassIVE
TranscriptomicsTranscription profiling of porcine alveolar macrophages (PAM) after antibody-mediated crosslinking of sialoadhesin (Sn, Siglec-1)
In the present study, Sn expressed on primary pig macrophages was crosslinked with the anti-Sn monoclonal antibody 41D3 and the mRNA expression profiles were compared, using the Affymetrix microarray technology, to macrophages incubated with the irrelevant, isotype matched, monoclonal antibody 13D12
ORGANISM(S): Sus scrofa 
2007-03-09 | E-MEXP-991 | biostudies-arrayexpress
TranscriptomicsMulti-angled transcriptome analyses reveal chameleon-like behavior of macrophages in the porcine respiratory tract
Macrophages have a pivotal role during viral infections in pigs. By expressing cell surface receptors, macrophages become viral targets and reservoirs. In the case of upper respiratory tract infections, many viruses target the peripheral nasal mucosa. Recent in vivo and in vitro (primary nasal cell ...
ORGANISM(S): Sus scrofa 
2023-09-29 | E-MTAB-12120 | biostudies-arrayexpress
TranscriptomicsExpression data of influenza A infected human macrophages
Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 can lead to a rapidly progressive viral pneumonia leading to acute respiratory distress syndrome. There is increasing evidence suggests a role for virus-induced cytokine dysregulation in contributing to the pathogenesis of human H...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18816 | biostudies-arrayexpress
ProteomicsPhosphoproteomic characterization of infulenza A virus infected human macrophages
Human primary macrophages were infected with influenza A virus (H3N2/Udorn strain, HA 256) for 6 hrs or left untreated. Cells were collected and lysed with HEPES lysis buffer (50 mM HEPES, 150 mM NaCl, 1 mM EDTA, 1 % NP-40, pH 7.4) including protease and phosphatase inhibitor cocktails. The cell lys...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080717 | MassIVE
TranscriptomicsGenome-wide transcriptional response of primary alveolar macrophages (PAMs) following infection with porcine circovirus type 2
Porcine alveolar macrophages (PAMs) play impoartant role in innate immunity. Porcine circovirus type 2 (PCV2) has been identified as the causal agent of postweaning multisystemic wasting syndrome, an economically important multifactorial disease of the swine industry worldwide. We used microarrays t...
ORGANISM(S): Sus scrofa 
2011-07-26 | E-GEOD-30918 | biostudies-arrayexpress
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