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ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
OtherQuantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots.
Data from ProteomeXchange, PXD ID: PXD001719. Experiment: TAILS_freeNt, file: TAILS_B_freeNt.msf.mgf. Published as part of Proteomics. 2015 Feb 27 . From the Abstract: {{i}} According to the Arg/N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thalia...
ORGANISM(S): Ath1 
GPM32320014396 | GPMDB
Resource Reanalysis 
TranscriptomicsDifferential Response Following Spinal Cord Injury in EphA4 Knockout
Mice lacking the developmental axon guidance molecule EphA4 have previously been shown to exhibit extensive axonal regeneration and functional recovery following spinal cord injury. To assess mechanisms by which EphA4 may modify the response to neural injury, a microarray was performed on spinal co...
ORGANISM(S): Mus musculus 
2012-05-23 | E-GEOD-34430 | biostudies-arrayexpress
no omics definedTranscription profiling of human HeLa cells treated with various functional siRNAs to investigate RNAi off-targets
Human HeLa cells were treated with various functional siRNAs of different sequence targeting several genes (100 nM or 50 nM for 24 hours). There are two transfection groups - in the first, containing biological duplicates (A and B), the mock-transfected control samples are pooled as a Cy3 reference...
ORGANISM(S): Homo sapiens 
2006-03-01 | E-MEXP-668 | biostudies-arrayexpress
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
TranscriptomicsTissue Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis
Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed pre-existing disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperito...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22600 | biostudies-arrayexpress
TranscriptomicsDysregulated deltaNp63alpha negatively regulates p73-mediated maspin expression
The p53 homologue, p63, is critical for normal epidermal development. While overexpression of deltaNp63alpha has been reported in squamous cell cancers, the contribution of p63 to cancer pathogenesis remains unclear. We previously demonstrated that overexpressed deltaNp63alpha aberrantly maintains p...
ORGANISM(S): Mus musculus 
2013-02-26 | E-GEOD-34862 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of monocytes and microglia from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
The role of microglia and infiltrating monocytes in experimental autoimmune encephalomyelitis (EAE) pathogenesis has been controversial. To gain insight into their respective roles, we developed a method for differentiating between microglia and infiltrating monocytes in the CNS using CD44. We used ...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-59725 | biostudies-arrayexpress
ProteomicsPathway Analysis of Dominant CHIP E3 Ligase-Dependent Protein Steady State Changes Highlight a Role in Neuronal Cell Membrane Integrity Linked to the Actin Cytoskeleton
Functional integrity of the E3-ubiquitin ligase CHIP is essential for healthy aging in the brain. By virtue of its association with the core molecular chaperone machinery, studies into the physiological role(s) of CHIP have been dominated by its involvement in the quality control and degradation of ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD021404 | Pride
Human Neurons Proteomics Swath Mass spectrometry 
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