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MetabolomicsNeuronal tRNA modifications in Aplysia californica are repatterned during behavioral habituation
Transfer RNA (tRNA) modifications have been increasingly implicated as post-transcriptional regulators of basic neuronal functions. However, characterizing tRNA modification profiles in specific neural circuits that control well-defined behaviors is notoriously difficult due to the complexity of con...
2026-09-01 | MTBLS15420 | MetaboLights
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications (with acetylation pathway)
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000706 | BioModels
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications Made by Ageing-Related Signalling Pathways
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000705 | BioModels
TranscriptomicsPost-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity (Validation 1)
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called M-bM-^@M-^\isomiRsM-bM-^@M-^] adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence miRNA stability and efficiency of target repression. Here we show that th...
ORGANISM(S): synthetic construct 
2011-06-15 | E-GEOD-26916 | biostudies-arrayexpress
GenomicsRNA Post-transcriptional Modifications of an Early-Stage Large Subunit Ribosomal Intermediate
RNA Post-transcriptional Modifications of an Early-Stage Large Subunit Ribosomal Intermediate
PRJNA972686 | ENA
ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
ProteomicsHistone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map
In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that h...
ORGANISM(S): Trypanosoma cruzi 
2021-01-04 | PXD019104 | Pride
Post-translational modifications Trypanosoma cruzi Histone Trypanosomatids 
ProteomicsNumerous post-translational modifications of RNA polymerase II subunit Rpb4 link transcription to post-transcriptional mechanisms
Rpb4/7 binds RNA Polymerase II (Pol II) transcripts co-transcriptionally and accompanies them throughout their lives. By virtue of its capacity to interact with key regulators (e.g., Pol II, eIF3, Pat1) both temporarily and spatially, Rpb4/7 regulates the major stages of the mRNA lifecycle. Here we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-09-25 | PXD020511 | Pride
Post-translational modifications Rpb4 Mrna 
TranscriptomicsChemical modifications mark alternatively spliced and actively degrading messenger RNAs in Arabidopsis and humans
Post-transcriptional chemical modification of RNA bases is a widespread and physiologically relevant regulator of RNA maturation, stability, and function. While modifications are best characterized in short, noncoding RNAs such as transfer RNAs (tRNAs), growing evidence indicates that messenger RNAs...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-66224 | biostudies-arrayexpress
ProteomicsProteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-20 | MSV000082644 | MassIVE
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