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ModelsAmara2013 - PCNA ubiquitylation in the activation of PRR pathway
Mechanistic model of the Post-Replication Repair (PRR), the pathway involved in the bypass of DNA lesions induced by sunlight exposure and UV radiation. PRR acts through two different mechanisms, activated by mono- and poly-ubiquitylation of the DNA sliding clamp, called Proliferating Ce...
2024-09-02 | BIOMD0000000475 | BioModels
UnknownA mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.
Not available
S-EPMC2447855 | biostudies-literature
ProteomicsProteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
SUMOylation is a form of post-translational modification involving covalent attachment of SUMO (Small Ubiquitin-like Modifier) polypeptides to specific lysine residues in the target protein. In human cells, there are four SUMO proteins, SUMO1–4, with SUMO2 and SUMO3 forming a closely related subfami...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080699 | MassIVE
UnknownXRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.
Not available
S-EPMC5572806 | biostudies-literature
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
UnknownNon-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.
Not available
S-EPMC3612035 | biostudies-literature
UnknownThe Homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells.
Not available
S-EPMC5599617 | biostudies-literature
ProteomicsPARP1-dependent DNA-protein crosslink repair
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also involved remains elusive. Here, we identify a DPC repair pathw...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-06 | PXD043107 | Pride
Xenopus Parp1 Top1 Dna-protein crosslink Adp-ribosylation Ddi2 Dna damage Ubiquitin Sumo P97 
TranscriptomicsExpression data from Saccharomyces cerevisiae strains carrying the rna14-1 or the rna15-1 allele
In the yeast Saccharomyces cerevisiae, cleavage factor I (CFI) and cleavage and polyadenylation factor (CPF) build the core of the transcription termination machinery. CFI comprises the Rna14, Rna15, Pcf11, and Clp1 proteins, as well as the associated Hrp5 RNA-binding protein. We found that CFI part...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-31 | E-GEOD-50947 | biostudies-arrayexpress
UnknownDirect interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
Not available
S-EPMC2901844 | biostudies-literature
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