Sort   by:  
 Page size 
ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-27 | MSV000084240 | MassIVE
ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus musculus (Mouse) 
2014-09-25 | PXD000590 | Pride
Brain Postsynaptic density Hippocampus Data-independent acquisition 
ProteomicsUnbiased proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes highly relevant to autism spectrum disorder
Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome (PMS), autism spectrum disorders (ASDs) and intellectual disability (ID). Although a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizin...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-08 | PXD005192 | Pride
Shank3 mutants Proteomics Hippocampus Striatum Postsynaptic density (psd) 
ProteomicsDevelopmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation
The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered during development. However, the dynamics of synaptic protein composition across development have not...
ORGANISM(S): Mus musculus (Mouse) Callithrix jacchus 
2024-01-17 | PXD048549 | Pride
Brain postsynaptic density mouse primate 
ProteomicsMutations in the postsynaptic signaling hub TNIK disrupts neuronal progenitor cells and immature neuronal function in human models of neurodevelopmental disease
Synaptic proteins, in particular those connected in large protein interaction networks at the postsynaptic site of glutamatergic neurons have been associated to a number of neurodevelopmental disorders. While their contribution to disease has been well documented in mature rodent synapses, their rol...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035004 | Pride
Neurodevelopment Hipsc Signaling networks Disease Postsynaptic Signaling 
ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
GenomicsBAI1 localises AMPA receptors at the cochlear afferent postsynaptic density and is
BAI1 localises AMPA receptors at the cochlear afferent postsynaptic density and is
PRJNA1069109 | ENA
ProteomicsPost-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases.
Posttranslational modifications with ubiquitin alter protein function and stability, thereby regulating cell homeostasis and viability, particularly under stress. Ischemic stroke induces protein ubiquitination at the periphery of the ischemic territory, wherein cells remain viable. Revealing the ide...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-06 | PXD042951 | Pride
Brain Phospho-proteomics Ubiquitin-enrichment Mouse Ischemic stroke Detergent-insoluble Nanolc-ms/ms Cerebral cortex 
ProteomicsStress-induced changes in the S-palmitoylation and S-nitrosylation of proteins involved in synaptic plasticity
Summary The precise regulation of synaptic integrity is critical for neuronal network connectivity and proper brain function. Essential aspects of the activity and localization of synaptic proteins are regulated by posttranslational modifications. S-palmitoylation is a reversible covalent modificati...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD010822 | Pride
Ptm's interplay Cell signaling Mass spectrometry Postsynaptic density synapse Nitrosylation palmitoylation 
ProteomicsDevelopmental profile of core postsynaptic density protein complexes integrates signaling components of brain disorders
The postsynaptic density (PSD) contains a collection of scaffold proteins used for the assembly of synaptic signaling complexes and disruption of this signaling machinery might be implicated in a variety of brain disorders. However, it is not known how the core-scaffold machinery associates this col...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-22 | PXD006277 | Pride
Neuron Synaptic Psd 
Sort   by:  
 Page size