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GenomicsGene expression profile of B55a/PPP2R2A knocked-down Parkin-expressing HeLa cells
Gene expression profile of B55a/PPP2R2A knocked-down Parkin-expressing HeLa cells
PRJNA1314588 | ENA
TranscriptomicsGene expression profile of B55a/PPP2R2A knocked-down Parkin-expressing HeLa cells
Or study identified the PP2A-B55a/PPP2R2A Ser-Thr phosphatase as a regulator of Parkin-dependent mitophagy and mitochondrial biogenesis. HeLa cells expressing Parkin and knocked-down for B55a/PPP2R2A induce a lysosome- and mitochondria-related transcriptional programmes down-stream TFEB and PGC-1a t...
ORGANISM(S): Homo sapiens 
2025-09-07 | GSE307113 | GEO
ProteomicsThe PP2A-B55-alpha phosphatase is a master regulator of mitochondrial degradation and biogenesis
Mitochondrial homeostasis relies on a tight balance between mitochondrial biogenesis and degradation. Although mitophagy is one of the main pathways involved in the clearance of damaged or old mitochondria, its coordination with mitochondrial biogenesis is poorly characterized.Here,by unbiased ap...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-24 | PXD065566 | Pride
Mitophagy Mitochondrial biogenesis Size exclusion chromatography Phosphatase 
ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 1/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD043098 | Pride
Wdr61 (ski8) Ung Ttc33 Pp2a Sf3ab Ski complex Paf complex Neurotransmitter Ccdc97 Ppp2r2a (b55a) Cga Hormone Phf5a 
TranscriptomicsGenome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number)
Primary plasma cell leukaemia (pPCL) is a rare, yet aggressive form of de novo plasma cell tumor, distinguished from secondary PCL (sPCL) which represents a leukemic transformation of pre-existing multiple myeloma (MM). Here, we performed a comprehensive molecular analysis of a prospective series of...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-39380 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations
This SuperSeries is composed of the following subset Series: GSE39380: Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) GSE39381: Genome-wide analysis of primary plasma cell leukemia identifies recu...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-39383 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the thebiological risk factors associated with PCa disparities observed in AA and EA patients, we performed microRNA profiling using Agilent Human miRNA a...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64318 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the biological factors accounting for the PCa disparities observed in AA and EA patients, we performed gene profiling analysis using Affymetrix human exon...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64331 | biostudies-arrayexpress
TranscriptomicsMicroRNA and Gene expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64333 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the prostate biopsy samples (cancer and adjacent normal tissues) from African American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the biological factors accounting for the PCa disparities observed in AA and EA patients, we performed gene profiling using Affymetrix human exon 1.0 ST a...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-71781 | biostudies-arrayexpress
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