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ProteomicsUstilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities
Diversification of effector function, driven by a co-evolutionary arms race, enables pathogens to establish compatible interactions with hosts. Structurally conserved plant pathogenesis-related PR-1 and PR-1-like (PR-1L) proteins are involved in plant defense and fungal virulence, respectively. It i...
ORGANISM(S): Ustilago maydis (Smut fungus) 
2023-08-29 | PXD044915 | Pride
Ustilago maydis Cape-like Fungal virulence Cathepsin b-like 3 Pry1 Phenolic resistance Pr-1-like Cnyd motif 
ProteomicsUstilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities
Diversification of effector function, driven by a co-evolutionary arms race, enables pathogens to establish compatible interactions with their hosts. Structurally conserved plant pathogenesis-related PR-1 and PR-1-like (PR-1L) proteins are involved in plant defense and fungal virulence, respectively...
ORGANISM(S): Zea Mays Ustilago Maydis 
2024-03-22 | PXD041022 | JPOST Repository
UnknownA PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts.
Not available
S-EPMC3381157 | biostudies-literature
UnknownUstilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities.
Not available
S-EPMC10505147 | biostudies-literature
TranscriptomicsMaintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch
Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like “triple negative” (TN) cancers lack steroid receptors but are cytokeratin (CK) 5-positive and require chemotherapy. Here we show that over half of primary ER+PR+ breast cancer...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-31870 | biostudies-arrayexpress
TranscriptomicsMaintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch
Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like “triple negative” (TN) cancers lack steroid receptors but are cytokeratin (CK) 5-positive and require chemotherapy. Here we show that over half of primary ER+PR+ breast cancer...
ORGANISM(S): Homo sapiens 
2011-12-21 | GSE31870 | GEO
TranscriptomicsRNA-seq analysis of total RNA from inflorescence stems of Arabidopsis Col-0, ccr-1, fer-4 and ccr-1/fer-4
A. thaliana lines with reduced lignin content through down-regulation of the lignin biosynthesis enzymes cinnamoyl CoA reductase (CCR) exhibit extensive cell wall remodeling which results in the release of a mixture of pectic oligosaccharide elicitors of pathogenesis-related (PR) protein gene expres...
ORGANISM(S): Arabidopsis thaliana 
2023-03-20 | GSE210734 | GEO
TranscriptomicsProgesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes
Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer models. Stable expression of PR-B in PR-low/ER+ MCF7 cells increased cellular sensitivity to estradiol and insulin-lik...
ORGANISM(S): Homo sapiens 
2015-03-15 | GSE45643 | GEO
ProteomicsTranslation deficits drive C9orf72 associated poly-GR/PR toxicity
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients with the C9orf72 mutation show predominantly cytoplasmic aggregates of poly-GR and poly-PR proteins that are acutely toxic in various model systems. To identify the molecular mediators of neurotoxicity of poly-GR/PR, we a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-06-27 | PXD008691 | Pride
Ftld Proteomics Stress granules Als Ribosome Nucleolus Dpr proteins Interactome C9orf72 Translation 
TranscriptomicsSingle-cell Transcriptome Analyses Reveal Unique Microglia Types Associated with Retinal Pathological Angiogenesis
We used single cell RNA-seq to comprehensively map all retinal microglia populations in a mouse model of oxygen-induced PR. We unveiled several unique types of PR-associated microglia (PRAM) and identified markers, signaling pathways, and regulons associated with these cells. Among these microglial ...
ORGANISM(S): Mus musculus 
2023-01-17 | GSE199792 | GEO
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