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MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
ProteomicsIntegrative Plasma Proteomics and Myeloid-Interferon Profiling Reveal an AI-Validated Vascular-Endothelial Stress Signature Distinguishing SLE Flare from Remission in an Indian Cohort A Discovery – Phase Study
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like the British Isles Lupus Assessment Group (BILAG) score, reliable molecular biomarkers for monitoring d...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD075349 | Pride
Biomarker Shap values Explainable ai (xai) Cytokine Multi-omics Machine learning Proteomics Precision medicine 
ProteomicsMetabolic control of inflammation by selenium
Trace element selenium (Se) is incorporated as the 21st amino acid, selenocysteine (Sec), into selenoproteins through tRNA[Ser]Sec. Selenoproteins act as gatekeepers of redox homeostasis and modulate immune function to effect anti-inflammation and resolution. However, mechanistic underpinnings invol...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD023005 | Pride
Proteomics Macrophages Succinate dehydrogenase Selenium 
MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
UnknownPhase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Not available
S-EPMC6075856 | biostudies-literature
Unknown(E)-N'-(3-Bromo-5-chloro-2-hy-droxy-benzyl-idene)nicotinohydrazide.
Not available
S-EPMC3201283 | biostudies-literature
TranscriptomicsAge Map, Cerebellum (A)
To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged...
ORGANISM(S): Mus musculus 
2009-06-21 | E-GEOD-8409 | biostudies-arrayexpress
UnknownApplication of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV.
Not available
S-EPMC12278831 | biostudies-literature
UnknownAntagonistic histone post-translational modifications improve the fidelity of epigenetic inheritance - a Bayesian perspective.
Not available
S-EPMC12513102 | biostudies-literature
ProteomicsIncreasing Pexophagy as an Unconventional Mode to Kill Cancer Cells
The autophagy-mediated degradation of peroxisomes, pexophagy, serves as a rheostat for peroxisome homeostasis. However, disturbing this process has yet to be investigated in the context of therapy treatment and resistance in cancer. In Vorinostat (Vor)-resistant lymphoma (B8) cells, an autophagosom...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD013926 | Pride
Metabolism Autophagy Cancer Exportomer Peroxisome Pexophagy 
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