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UnknownQuantifying the mechanism of phosphate monoester hydrolysis in aqueous solution by evaluating the relevant ab initio QM/MM free-energy surfaces.
Not available
S-EPMC3797183 | biostudies-literature
ProteomicsHematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system
Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD057783 | Pride
Autophagy Proteomics Cancer stem cells Hsp Hematopoietic stem cells Tropism Conditioned media 26s proteasome Colorectal cancer 
ProteomicsPhosphoproteomic analysis of Protein Phosphatase PfPPM2/PP2C mutant of Plasmodium falciparum 3D7
PfPPM2, a protein phosphatase, plays a key role in regulating both the asexual and sexual development of the human malaria parasite P. falciparum. To understand the mechanisms by which PfPPM2 influences this process, it was essential to identify its targets or substrates within the parasite. To achi...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-04-08 | PXD055390 | Pride
Phosphoproteomics Plasmodium falciparum Tmt labelling Orbitrap fusion. 
ProteomicsExploring molecular dynamics indicators associated with reproductive performance of Bos indicus cattle in plasma samples through data-independent acquisition mass spectrometry
Aim of the study was to profile the blood plasma proteome of healthy Bos indicus cattle and use it as a baseline against which to compare different conditions in Bos indicus cattle, such as disease, reproduction associated proteins and pregnancy specific proteins etc. Data-independent acquisition (D...
ORGANISM(S): Bos taurus (Bovine) 
2024-07-15 | PXD034103 | Pride
Lc-ms/ms-dia Bos indicus Quantitative proteomics Plasma Animal reproduction Diary research 
UnknownCrystal structure of (E)-2-(furan-2-yl-methyl-idene)-2,3,4,9-tetra-hydro-1H-carbazol-1-one.
Not available
S-EPMC5778486 | biostudies-literature
UnknownGenome-wide dissection of AT-hook motif nuclear-localized gene family and their expression profiling for drought and salt stress in rice (Oryza sativa).
Not available
S-EPMC10749976 | biostudies-literature
UnknownNovel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography.
Not available
S-EPMC9072675 | biostudies-literature
ProteomicsA Cell-based Systems Biology Assessment of Human Blood to Monitor Immune Responses After Influenza Vaccination
Systems biology is an approach to comprehensively study complex interactions within a biological system. Most published systems vaccinology studies have utilized whole blood or peripheral blood mononuclear cells (PBMC) to monitor the immune response after vaccination. Because human blood is compris...
ORGANISM(S): Homo sapiens (Human) 
2015-01-08 | PXD001657 | Pride
Human Systems vaccinology Vaccine response Immune response Blood Immune cells Quantitative proteomics Itraq Tiv 
ProteomicsDiscovery and Validation of Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases
Early detection of colorectal cancer (CRC) and distinguishing inflammatory bowel diseases from cancerous conditions significantly improve survival rates. While colonoscopy is the gold standard for CRC detection, it is invasive and associated with potential complications. Therefore, there is a need f...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD065161 | Pride
Colonoscopy Serum biomarkers Pre-diagnosis Cancer Neoantigen 
MetabolomicsSequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
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