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We determined which metabolic pathways are activated by hypoxia-inducible factor 1-mediated (HIF-1-mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...
2019-07-05 | MTBLS856 | MetaboLights

N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights
Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neov...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052730 | Pride
GENEVA GWAS of Prematurity and its Complications - European Ancestry
GENEVA GWAS of Prematurity and its Complications - African Ancestry
Clinical and Genetic Analysis of Retinopathy of Prematurity-GWAS
Clinical and Genetic Analysis of Retinopathy of Prematurity-GWAS
Prematurity alters the progenitor cell program of the upper respiratory tract of neonates
Clinical and Genetic (Whole Exome Sequences) Analysis of Retinopathy of Prematurity
Clinical and Genetic (Whole Exome Sequences) Analysis of Retinopathy of Prematurity
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