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MetabolomicsUntargeted and Targeted Plasma Metabolomics Analysis Identifies Aberrant Amino Acid Metabolism in Early Primary Angle-Closure Glaucoma

Purpose: To explore the plasma metabolite profiles of patients with early primary angle-closure glaucoma (PACG) and investigate their relevance to ocular characteristics and retinal-associated parameters.

Methods：Plasma samples were obtained from 30 early PACG patients and 30 healthy contro...

2026-01-06 | MTBLS13608 | MetaboLights
ProteomicsPrimary angle closure glaucoma is characterized by altered extracellular matrix homeostasis in the iris
Purpose. To characterize the proteome of the iris in primary angle closure glaucoma (PACG). Experimental Design. In this cross-sectional study, iris samples were obtained from surgical iridectomy of 48 adults with PACG and five normal controls. Peptides from iris were analyzed using liquid chromatog...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD022292 | Pride
Eye Proteomics Primary angle closure glaucoma Iris Extracellular matrix 
ProteomicsComparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and senile cataract eyes
Comparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and senile cataract eyes
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD004928 | Pride
Proteomics Glaucoma Cataract 
TranscriptomicsTranscription profiling of mouse model of glaucoma retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation
Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analys...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-3554 | biostudies-arrayexpress
UnknownBlindness in glaucoma: primary open-angle glaucoma versus primary angle-closure glaucoma-a meta-analysis.
Not available
S-EPMC9582001 | biostudies-literature
UnknownRacial and Sociodemographic Disparities in the Detection of Narrow Angles before Detection of Primary Angle-Closure Glaucoma in the United States.
Not available
S-EPMC9309181 | biostudies-literature
UnknownDifferences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study.
Not available
S-EPMC7956120 | biostudies-literature
UnknownRates and Patterns of Diagnostic Conversion from Anatomical Narrow Angle to Primary Angle-Closure Glaucoma in the United States.
Not available
S-EPMC9978040 | biostudies-literature
UnknownThe genetic mechanisms of primary angle closure glaucoma.
Not available
S-EPMC4815686 | biostudies-literature
UnknownGlaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study.
Not available
S-EPMC8286291 | biostudies-literature
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