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TranscriptomicsSmoking is Associated with Shortened Airway Cilia
Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting cilia length must exceed th...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-16696 | biostudies-arrayexpress
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
TranscriptomicsGene expression in control and cilia deleted growth plate chondrocytes
Proliferative zone chondrocytes were microdissected from control and Ift88-deleted growth plates to determine gene expression profiles regulated by primary cilia. Four total samples were analyzed. Two biological replicates of proliferative zone chondrocytes microdissected from control mice and two b...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-35003 | biostudies-arrayexpress
ProteomicsProteome expression profile of primary cilia deficient mIMCD3 cells
We characterized the protein expression profiles in ciliated kidney tubular epithelial cells and studied the changes upon loss of primary cilia.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD035290 | Pride
Cilia Autophagy Ripk3 Ciliopathies Nphp Kidney Necroptosis 
ProteomicsPrimary Cilia-Mediated Regulation of Microglial Secretion in Alzheimer's Disease
Proteomic approaches revealed that primary cilia, small hair-like structures found on cells, played a role in the regulation of microglial secretory function. Notably, primary cilia were transiently observed in less than 10% of microglia, and their presence was significantly reduced in microglia fro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043328 | Pride
Microglia Primary cilia Alzheimer's disease 
TranscriptomicsGenome-wide gene expression analysis in primary ciliary dyskinesia patients
We performed whole genome gene expression profiling in bronchial biopsies from PCD patients. We used the Quality Threshold clustering algorithm to identify groups of genes that revealed highly correlated RNA expression patterns in the biopsies. The largest cluster contained 372 genes and was signifi...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-25186 | biostudies-arrayexpress
ProteomicsDSSO Crosslinking of Intact Tetrahymena Thermophila Cilia
The MS-cleavable crosslinker, DSSO, was added to cilia isolated from Tetrahymena thermophila. After digestion crosslinked peptides were enriched by size exclusion chromatography. Data were collected using an MS2/MS3 method. Analysis was done using the XlinkX node of PD2.3 and a fasta file generat...
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911) 
2022-07-19 | MSV000089917 | MassIVE
GenomicsPrimary cilia control translation and the cell cycle in medulloblastoma
Primary cilia control translation and the cell cycle in medulloblastoma
PRJNA853310 | ENA
ProteomicsPrimary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant brain tumor in infants and is characterized by loss of nuclear SMARCB1 protein expression. Recent studies show that AT/RTs comprise three molecular subgroups with epigenetic differences, including distinct expression patterns of g...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027211 | Pride
Atypical teratoid/rhabdoid tumor Targeted therapy Stat1/dr5 signaling Primary cilia 
GenomicsPrimary cilia sensing-regulated transcriptome in the collecting duct
Primary cilia sensing-regulated transcriptome in the collecting duct
PRJNA431759 | ENA
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