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ProteomicsNematostella extracellular matrix proteome of planula, primary polyp and adult
The aim of this project was to identify all proteins that are part of the extracellular matrix of Nematostella and to investigate the molecular dynamics that occur in different life stages of the complex life cycle with a special focus on the metamorphosing of the planula-polyp transition. Decellula...
ORGANISM(S): Nematostella vectensis 
2025-10-01 | PXD045345 | Pride
Ecm Life stages Matrisome Mesoglea Planula Primary polyp 
TranscriptomicsA global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulati...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-39957 | biostudies-arrayexpress
TranscriptomicsPolyphosphate affects gene expression and viability of Porphyromonas gingivalis W83
Polyphosphate (polyP) is a ubiquitous and abundant compound found in bacteria, fungi, algae, plant, and animals. Among roles of intracellular polyP in bacteria are resistance and survival in the stationary phase of the growth against stress and stringent condition. Therefore, intracellular polyP is ...
ORGANISM(S): Porphyromonas gingivalis 
2008-05-30 | E-GEOD-11471 | biostudies-arrayexpress
GenomicsRNA-seq of Nematostella POU4 mutants at primary polyp stage
RNA-seq of Nematostella POU4 mutants at primary polyp stage
PRJEB36185 | ENA
TranscriptomicsRNA-seq of Nematostella POU4 mutants at primary polyp stage
A loss of function mutation of the Nematostella vectensis POU4 gene was generated by CRISPR/Cas9. Homozygous mutants lack a cell type that can be identified by light microscopy in live animals. Homozygous mutants were separated from siblings based on this phenotype, this approach had been validated ...
ORGANISM(S): Nematostella vectensis 
2020-01-23 | E-MTAB-8658 | biostudies-arrayexpress
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but dev...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47735 | biostudies-arrayexpress
TranscriptomicsExpression data from T-cells isolated from healthy mice or mice with polyposis
There is much controversy about the role of T-regulatory cells (Treg) in human colon cancer. High densities of tumor-infiltrating Treg can correlate with better or worse clinical outcomes depending on the sutdy. Treg have potent anti-inflammatory functions that have been shown to control cancer prog...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-41229 | biostudies-arrayexpress
GenomicsNasal Polyp RNAsequencing, Skaraborg Sweden
Whole-transcriptome sequencing (RNAseq) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and controls. Differential expression patterns in genes involved in cilia, viral defense and NKT-cell specific pathways, suggesting a role of viral immunity in combination with cilia functional...
EGAS00001007088 | EGA
TranscriptomicsGenomic studies of colorectal polyps and concurrent cancer
The well-known colorectal adenoma-carcinoma sequence suggests that a normal epithelial cell, through accumulations of genetic lesion and epigenetic disregulation can transform into a benign adenoma then further develop into a cancer. Using microarray-based comparative genomic hybridization (CGH), we...
ORGANISM(S): Homo sapiens 
2011-06-30 | E-MEXP-3149 | biostudies-arrayexpress
UnknownIsolation, cultivation, and application of primary respiratory epithelial cells obtained by nasal brushing, polyp samples, or lung explants.
Not available
S-EPMC9157560 | biostudies-literature
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