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MetabolomicsSingle-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis

Raw data of both bulk and single-cell metabolomics. It includes all MS, LC-MS and LC-MS/MS raw data associated with the article 'Single-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis'.

2026-02-14 | MTBLS13900 | MetaboLights
TranscriptomicsTranscription profiling of rice cells reveal bacterial lipopolysaccharides induce defense responses associated with programmed cell death
PAMP (Pathogen-Associated Molecular Pattern) recognition plays an important role in innate immune responses both in plants and animals. Lipopolysaccharides (LPS) of gram-negative bacteria are a typical PAMP molecule and have been reported to induce defense-related responses such as suppression of hy...
ORGANISM(S): Oryza sativa 
2008-11-06 | E-GEOD-5906 | biostudies-arrayexpress
ProteomicsCombined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
AKT activation is a hallmark of IM resistance in GIST. The presence of an additional therapeutic agent could potentially suppress the growth and survival of a clone of cancer cells, which have developed resistance to IM. Simultaneous targeting of AKT in addition to inhibiting KIT with IM has potenti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086739 | MassIVE
TranscriptomicsChloroplast-dependent programmed cell death is activated in Arabidopsis cell cultures after singlet oxygen production by Rose Bengal
Arabidopsis thaliana cell suspension cultures (ACSC) were subjected to 30-min, mild chemical treatments with three different singlet oxygen elicitors at low-medium light conditions (150 µE m–2 s–1) with the aim of getting a better understanding of singlet oxygen-mediated defence responses in plants....
ORGANISM(S): Arabidopsis thaliana 
2014-03-13 | E-GEOD-43551 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli cells during cell death programmed by a restriction-modification system
Genetically programmed deaths play important roles in the biology of unicellular prokaryotic cells. Some gene complexes force their maintenance on the host bacterial cells by killing cells that have lost them. This form of programmed death called post-segregational killing or genetic addiction is br...
ORGANISM(S): Escherichia coli 
2009-07-04 | E-GEOD-7326 | biostudies-arrayexpress
MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
MetabolomicsExploring the Effects and Mechanisms of Curcumin on Proliferation, Apoptosis, and Oxidative Stress in Hepatoblastoma cell line via the TLR4/TRAF6/MAPKs Pathway

A combination of bioinformatics and network pharmacology was used to screen curcumin's target genes and related signaling pathways in treating hepatocellular carcinoma. Curcumin-Containing Serum（CUR） was prepared. Cisplatin(CDDP) served as the positive control .The CCK-8 assay, scratch assay, and...

2025-11-28 | MTBLS13412 | MetaboLights
ProteomicsBoundary of Life and Death: changes in mitochondrial and cytosolic proteomes of Arabidopsis thaliana suspension cells associated with programmed cell death
Despite the critical role of programmed cell death (PCD) in plant development and defence responses, its regulation is not fully understood. It has been proposed that mitochondria may control the early stages of plant PCD, but the details of this regulation are currently unknown. Here, we used Arabi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-07-01 | PXD040584 | Pride
Cytosol Proteomics Mitochondria Plant programmed cell death Heat stress 
ProteomicsComprehensive glycomic and glycoproteomic analysis of human programmed cell death protein 1 extracellular domain
Mass spectrometric analyses of N- and O-glycosylation on human programmed cell death protein 1 extracellular domain (hPD-1 ECD) that expressed by human embryonic kidney 293 (HEK 293) and Chinese hamster ovary (CHO) cells
ORGANISM(S): Homo Sapiens 
2024-01-22 | PXD048448 |
MetabolomicsDietary hispidulin ameliorated chemically-Induced colitis by inhibiting epithelial cell ferroptosis via the ACAT2-GPX4 axis and remodeling the gut microbiota

Hispidulin, a dietary flavonoid occurring naturally in brown algae, has attracted considerable interest owing to its functions in modulating inflammatory responses and neutralizing reactive oxygen species. This study examined the consequences of hispidulin in a model of chemically induced acute c...

2025-08-05 | MTBLS12818 | MetaboLights
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