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MetabolomicsA new perspective on semen quality of aged male: The characteristics of metabolomics and proteomics

BACKGROUND: Semen quality is negatively correlated with male age and is mainly quantified by a routine semen analysis, which is descriptive and inconclusive. Sperm proteins or semen metabolites are used as the intermediate or end-products, reflecting changes in semen quality, an...

2024-01-16 | MTBLS5289 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsProteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-13 | MTBLS12995 | MetaboLights
MetabolomicsProteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-14 | MTBLS12996 | MetaboLights
ProteomicsProteomics analysis of whole-cell, soma and neuronal projection fractions from day 35 iNeurons in Control and ASAH1-/-
This experiment describes the quantitative proteomic profiling of whole-cell, soma, and neuronal projection fractions from day 35 induced neurons (iN) derived from control and ASAH1 knockout human embryonic stem cells. Soma and projection compartments were physically separated using Transwell cultur...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD067229 | Pride
Pd In Ida Lysosome dysfunction Neurodegeneration Tmtpro Projection proteomics 
ProteomicsProjDIA: Fragment-Bin Projection Scoring and Calibrated Confidence for Direct Infusion DIA Proteomics
Direct-infusion shotgun proteome analysis (DI-SPA) increases throughput by removing liquid chromatography, but the resulting DIA spectra are highly multiplexed and difficult to interpret. This dataset was generated to evaluate ProjDIA, a computational workflow for direct-infusion DIA proteomics. Pro...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD076477 | Pride
Mcf7 Proteomics Projdia Direct infusion Dia Species entrapment Di-spa Hela Label-free quantification 
TranscriptomicsmRNA-Seq expression and MS3 proteomics profiling of human post-mortem BA9 brain tissue for Parkinson Disease and neurologically normal individuals
Parkinson disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy Bodies” within neurons. PD has both genetic and environmental risk factors, and while processes leading to aberrant protein aggregation ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-68719 | biostudies-arrayexpress
UnknownQuantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Not available
S-EPMC7950107 | biostudies-literature
ProteomicsHigh-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning
We develop a parallel flow projection and transfer learning-based spatial proteomics framework that combines microfluidics and a deep neutral network.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-01-15 | PXD045687 |
UnknownMolecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units.
Not available
S-EPMC4744103 | biostudies-literature
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