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ProteomicsEvaluation of N8-propargyl spermidine (Probe 1) as a substrate of deoxyhypusine synthase in cellulo
Two complementary experiments were performed to evaluate whether N8-propargyl spermidine is a substrate of deoxyhypusine synthase in cells. HEK293 and mouse embryonic fibroblast (MEF) cells were incubated with either N8-propargyl spermidine (Probe 1) or spermidine, lysed, and subjected to CuAAC liga...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-23 | PXD080059 | Pride
N8-propargyl spermidine Mef Chemical probe Hypusination Hek293 
ProteomicsThio-triazole-biotin-labeled peptides derived from iPA probes
iPAs are minimal-tag chemical probes - propargyl analogs of putrescine (PUT), spermidine (SPD), and spermine (SPM) - that preserve charge/spacing, retain transporter compatibility, and enable high-resolution intracellular imaging following paraformaldehyde (PFA)-based crosslinking and copper-catalyz...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070115 | Pride
Artificialy modified peptides Propargyl tag Polyamines 
ProteomicsAMpylation is a hallmark of human neuronal differentiation
The AMPylation is novel protein post-translation modification. In consist of attachment of the adenosine monophosphate onto the serine, threonine or tyrosine amino acid residues of the protein. This process is catalysed by bacterial effectors or in human by protein FICD (also called HYPE) which cont...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD008394 | Pride
Chemical-proteomics Cerebral organoids. Phosphoramidate prodrugs Ficd Ampylation Neuronal development 
ProteomicsFICD activity and AMPylation remodelling modulate human neurogenesis
The AMPylation is novel protein post-translation modification. In consist of attachment of the adenosine monophosphate onto the serine, threonine or tyrosine amino acid residues of the protein. This process is catalysed by bacterial effectors or in human by protein FICD (also called HYPE) which cont...
ORGANISM(S): Homo sapiens (Human) 
2019-12-04 | PXD015062 | Pride
Chemical-proteomics Cerebral organoids. Phosphoramidate prodrugs Ficd Ampylation Neuronal development 
UnknownSuper silyl-based stable protecting groups for both the C- and N-terminals of peptides: applied as effective hydrophobic tags in liquid-phase peptide synthesis.
Not available
S-EPMC10189889 | biostudies-literature
UnknownTowards Engineering an Orthogonal Protein Translation Initiation System.
Not available
S-EPMC8576571 | biostudies-literature
UnknownA SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells.
Not available
S-EPMC10624628 | biostudies-literature
UnknownSite-specifically arraying small molecules or proteins on DNA using an expanded genetic alphabet.
Not available
S-EPMC3983968 | biostudies-literature
UnknownCapture, Release, and Identification of Newly Synthesized Proteins for Improved Profiling of Functional Translatomes.
Not available
S-EPMC9971285 | biostudies-literature
ProteomicsIn-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane- Permeable, and Alkynyl-Enrichable Crosslinker
Chemical crosslinking coupled with mass spectrometry (CXMS) has emerged as a powerful technique to obtain the dynamic conformations and interaction interfaces of protein complexes. Limited by the poor cell membrane permeability, chemical reactivity, and biocompatibility of crosslinkers, in vivo cros...
ORGANISM(S): Homo Sapiens (human) 
2022-08-05 | PXD035826 | JPOST Repository
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