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ProteomicsTracking Proteasome Degradation: A Cross-Organ Analysis via Intact degradomics Top-Down Mass Spectrometry
Identifying the peptides generated by the proteasome is essential for understanding its role in regulating critical cellular processes such as apoptosis, signaling, and immune responses. In this study, we introduce an enzymatic top-down mass spectrometry approach that allows real-time monitoring of ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD058121 | Pride
Mass spectrometry Top-down ms Proteasome Protein degradation 
ProteomicsGlobal Subcellular Characterization of Protein Degradation Using Quantitative Proteomics
Protein degradation provides an important regulatory mechanism used to control cell cycle progression and many other cellular pathways. To comprehensively analyze the spatial control of protein degradation in U2OS osteosarcoma cells, we have combined drug treatment and SILAC-based quantitative mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080816 | MassIVE
TranscriptomicsTranscription profiling by array of human HEK293 cells treated with the proteasome inhibitor epoxomicin
The objective of this study is to identify the genes that are up-regulated amid proteasome dysfunction to facilitate the discovery of proteolytic pathways that are activated as a compensatory response to proteasome inhibition. Proteasome is a large multi-component proteolytic complex in the cell. It...
ORGANISM(S): Homo sapiens 
2009-01-27 | E-GEOD-14429 | biostudies-arrayexpress
ProteomicsProteasome degradation of synthetic ubiquitinated globin
Analysis of the peptides resulting from proteasome-mediated degradation of K48-linked tetra ubiquitin conjugated to alpha globin
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD004456 | Pride
Human 26s proteasome Alpha globin Ubiquitin 
ModelsSneppen2009 - Modeling proteasome dynamics in Parkinson's disease
Sneppen2009 - Modeling proteasome dynamics in Parkinson's disease This model is described in the article: Modeling proteasome dynamics in Parkinson's disease. Sneppen K, Lizana L, Jensen MH, Pigolotti S, Otzen D. Phys Biol 2009; 6(3): 036005 Abstract: In Parkinson's d...
2024-09-02 | BIOMD0000000548 | BioModels
TranscriptomicsSynergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
The experiments were designed to interrogate the genetic interaction relationship between the TOR signalling pathway and the UPS-proteasome pathway in gene expression and cell growth. Yeast cells (BY4742pdr5delta) were treated with the drug vehicle, MG132 (50uM), rapamycin (200ng/ml) or both drugs. ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-24 | E-MTAB-1550 | biostudies-arrayexpress
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
TranscriptomicsDistinct Protein Degradation Induced by Different Disuse Models of Skeletal Muscle Atrophy
Skeletal muscle atrophy is a consequence of many diseases, environmental insults, inactivity, age and injury. Atrophy is characterized by active degradation and removal of contractile proteins and a reduction in fiber size. Animal models have been extensively used to identify pathways leading to a...
ORGANISM(S): Mus musculus 
2011-10-24 | E-GEOD-25908 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
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