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MetabolomicsAssessment of automated trimethylsilyl derivatisation protocols for GC-MS-based untargeted metabolomic analysis of urine
GC-MS is a commonly used metabolomic platform for the analysis of urine. A key step in the preparation of samples for GC-MS is derivatisation, in particular, methoximation and trimethylsilylation. This paper presents an assessment of automated derivatisation protocols for GC-MS-based untargeted meta...
2015-09-28 | MTBLS171 | MetaboLights
ProteomicsWidespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
The Jumonji domaining-containing protein JMJD6 is a 2-oxoglutarate dependent dioxygenase that has been implicated in a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicing and co-transcriptional processing. Al...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-08-02 | PXD031221 | Pride
Human Lc-msms Hydroxylation Jmjd6 Lysine derivatisation 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
ProteomicsFASIL-MS: An Integrated Proteomic and Bioinformatic Workflow to Universally Quantitate In vivo-acetylated Positional Isomers
Dynamic changes in histone post-translational modifications (PTMs) regulate gene transcription leading to fine-tuning of biological processes such as DNA replication and cell cycle progression. Moreover, specific histone modifications constitute docking sites for recruitment of DNA damage repair pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2016-06-16 | PXD003611 | Pride
Ms2-based quantitation Lysine deacetylase inhibitor Histone acetylation Mass spectrometry N-acetoxy-d3-sucinnimide Fasp Protein derivatisation 
UnknownPower to the protein: enhancing and combining activities using the Spy toolbox.
Not available
S-EPMC7844731 | biostudies-literature
UnknownEffluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients.
Not available
S-EPMC5772620 | biostudies-literature
UnknownSynthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.
Not available
S-EPMC4839272 | biostudies-literature
ProteomicsDisrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Propionate is a common three-carbon intermediate produced from the breakdown of propiogenic substrates, such as branched-chain amino acids and odd-numbered fatty acids, and by gut bacteria. Propionate can chemically modify proteins, and if this involves histones, it may underpin a disease-relevant l...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-09-29 | PXD043513 | Pride
Heart failure Histone Contraction Epigenetics Propionic acidemia 
Unknown5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Not available
S-EPMC4678600 | biostudies-literature
MetabolomicsResource Partitioning of Diatom Metabolites that Support Bacterial Heterotrophy in the Ocean (UPLC-MS assay)

The communities of marine bacteria that assemble around living microphytoplankton are predictably dominated by three taxonomic groups, each of which specializes in different components of the available metabolite pool: Rhodobacterales transport small and polar metabolites, Flavobacteriia use carb...

2020-09-15 | MTBLS1751 | MetaboLights
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