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TranscriptomicsBuffering and proteolysis are induced upon segmental haploidy in Drosophila melanogaster.
Aneuploidy, i.e., variation in the number of individual chromosomes (chromosomal aneuploidy) or chromosome segment (segmental aneuploidy) is associated with developmental abnormalities and reduced fitness in all species examined, is the leading cause of miscarriages and mental retardations and a hal...
ORGANISM(S): Drosophila melanogaster 
2012-04-04 | E-GEOD-34400 | biostudies-arrayexpress
TranscriptomicsGene Dosage, Mainly 3q Amplification, Deregulates a Quarter of Genes in Cervical Cancer: It Induces Glycolysis, Anaphase-dependent Proteasome Proteolysis, and Low Survival
The contribution of copy number (CN)-altered genes in cervical carcinogenesis is unknown owing to a lack of correlation with gene expression. We mapped CN-altered genes in 31 cervical cancers (CCs), and investigated the expression of 21,000 genes in 55 CCs using microarrays. Biological processes ass...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-52903 | biostudies-arrayexpress
ProteomicsDual Protease-Mediated Proteolysis Coupled with Ultrafiltration for System-Level Profiling of Drug Targets and Conformational Dynamics: cell level
Dual Protease-Mediated Proteolysis Coupled with Ultrafiltration for System-Level Profiling of Drug Targets and Conformational Dynamics
ORGANISM(S): Homo Sapiens 
2025-11-24 | PXD071125 |
ProteomicsMass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis
Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of...
ORGANISM(S): Homo sapiens (Human) 
2020-10-15 | PXD020858 | Pride
Proteolysis Mass spectrometry Amyloid fibrils Proteomics Cardiomyopathy 
ProteomicsProteolysis pattern of two variants of Chickpea using LC-MS/MS
Despite the importance of grains and legumes in the human diet, little is known regarding peptide release and the temporal changes of protease activities during seed germination. LC/MS-MS peptidomic analysis of two cultivars of germinating chickpea followed by computational analyses indicated clea...
ORGANISM(S): Cicer arietinum (Chickpea) (Garbanzo) 
2024-07-18 | PXD048224 | Pride
Peptidomics Proteolysis pattern Plant seed proteins 
ProteomicsEndogenous human milk proteolysis as a function of pH
The use of human milk products is increasing for high-risk infants. Human milk contains endogenous enzymes that comprise a dynamic proteolytic system; yet, biological properties of these enzymes and their activities in response to variations including pH within infants are unclear. This study was de...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012748 | Pride
Human Peptide Endogenous proteolysis Q exactive Ph Milk 
ProteomicsFLiPPR: A Processor for Limited Proteolysis (LiP) Mass Spectrometry Datasets Built on FragPipe
Here, we present FLiPPR, or FragPipe LiP (limited proteolysis) Processor, a tool that facilitates the analysis of data from limited proteolysis mass spectrometry (LiP-MS) experiments following primary search and quantification in FragPipe. LiP-MS has emerged as a method that can provide proteome-wid...
ORGANISM(S): Bacillus cereus (strain ATCC 14579 / DSM 31) 
2024-05-24 | PXD047776 | Pride
Data processing Proteomics Limited proteolysis Bacillus cereus atcc 14579 Bacilli Mass spectrometry Bioinformatics Bottom-up Data 
TranscriptomicsMicroarray data from pre-germinated seeds and hypoxia-treated seedlings of Arabidopsis prt6-1 and ate1 ate2 mutants of the N-end rule pathway of targeted proteolysis pathway
This study analyzes transcriptome profiles in pre-germinated seeds and hypoxia-treated seedlings of Arabidopsis thaliana wild type (Col-0) and homozygous mutants (prt6-1 and ate1 ate2). This dataset includes CEL files, RMA signal values and MAS5 P/M/A calls. For pre-germinated seeds, seeds imbibed f...
ORGANISM(S): Arabidopsis thaliana 
2011-10-22 | E-GEOD-29941 | biostudies-arrayexpress
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
TranscriptomicsHtrA1-dependent proteolysis of TGF-M-NM-2 controls both neuronal maturation and developmental survival
Transforming growth factor-M-NM-2 (TGF-M-NM-2) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid-M-NM-2 accumulation, apoptosis and excitotoxicity. Using cultured cortical neurons prepared from either wild type or transgenic mice over-expressing a ...
ORGANISM(S): Homo sapiens 
2008-04-15 | E-GEOD-11162 | biostudies-arrayexpress
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