Sort   by:  
 Page size 
ProteomicsIntegrative Multi-omics Characterization of 12 Syngeneic Mouse Models
Mouse syngeneic models serve as indispensable tools for elucidating tumor-immune interactions and assessing immunotherapy efficacy. In this study, we first conducted a comprehensive evaluation of six label-free protein quantification pipelines across 12 mouse syngeneic models, revealing that data-in...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD064638 | Pride
Proteomics data of mouse syngeneic models 
ProteomicsPhosphoproteomics Characterization of 12 Syngeneic Mouse Models
Mouse syngeneic models serve as indispensable tools for elucidating tumor-immune interactions and assessing immunotherapy efficacy. In this study, we first conducted a comprehensive evaluation of six label-free protein quantification pipelines across 12 mouse syngeneic models, revealing that data-in...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD064740 | Pride
Phosphoproteomics characterization of 12 syngeneic mouse models 
ProteomicsProteomics of Mouse Syngeneic Models
The cell line-derived xenografts and patient derived xenografts have limited use in cancer immunotherapy evaluation because an immune compromised host is required for xenotransplantation. Syngeneic mouse models are derived by transplanting established mouse cell lines or tumor tissues to strain matc...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-03 | PXD011885 | Pride
Mouse sygeneic Immuno-oncology Tumor 
ProteomicsHigh-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models
Introduction: Immune checkpoint inhibitors(ICIs) targeting programmed cell death protein 1 (PD1) confer significant survival benefits to patients with non-small cell lung cancer (NSCLC). However, there remains a substantial unmet need to identify therapeutic approaches to overcome resistance and pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD059688 | Pride
Lc-msms Mouse Lung cancer 
ProteomicsSTUB1 is an intracellular checkpoint for interferon gamma sensing
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms underlying ICB resistance. Results from a published CRISPR sc...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-18 | PXD035392 | Pride
Mouse melanoma cell lines 
ProteomicsOrganoid-trasplant model systems to study in vivo the effects of obesity on the pancreatic carcinogenesis
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality among adults in developed countries. The discovery of the most common genetic alterations as well as the development of organoids models of pancreatic cancer have provided insight into the fundamental path...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018362 | Pride
Carcinogenesis Obesity Organoid models Adipokines Pancreatic cancer 
ProteomicsAntigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model
A common cornerstone of preclinical cancer research is the use of syngeneic orthotopic murine tumors as immunocompetent models of human cancers. For glioblastoma research efforts, the GL261 and CT2A lines are frequently used. We systematically characterized these two lines to decipher the cell-intr...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-19 | PXD036720 | Pride
Ct2a Glioblastoma Immunotherapy Gl261 
ProteomicsRepurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer ImmunotherapyRepurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy
In this study, we show that intratumoral injections of the trivalent measles, mumps, and rubella (MMR) live attenuated viral vaccine (LAVs) modulate a potent cytotoxic T cells immune response, resulting in tumor growth inhibition and improved survival in syngeneic mouse models of hepatocellular ca...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-27 | PXD031295 | Pride
Colerectal cancer Measles Mumps Rubella hepatocellular carcinoma Mouse liver 
MetabolomicsVesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

Selective autophagy of mitochondria is known to promote survival and progression of cancer cells in various malignancies, including triple-negative breast cancer (TNBC). Here, we investigate the essential metabolic adaptations that support mitochondrial quality control in cancer cells with the ai...

2025-09-30 | MTBLS13037 | MetaboLights
ProteomicsTumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations. RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants....
ORGANISM(S): Mus musculus (Mouse) 
2024-03-15 | PXD047878 | Pride
Rmc-7977 Kpc Ras Pdac 
Sort   by:  
 Page size