Proteomics of secreted proteins

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Proteomics (1780)
Unknown (942)
Transcriptomics (40)
Genomics (35)
Metabolomics (14)
Other (11)
Multiomics (4)
Models (2)

Organisms

Homo sapiens (85)
Mus musculus (47)
Yersinia pestis CO92 (7)
Rattus norvegicus (5)
Haemaphysalis longicornis (5)
Solanum tuberosum (3)
Oryza sativa Japonica Group (3)
Escherichia coli (3)
Macaca nemestrina (2)
Bombyx mori (2)
Pseudomonas aeruginosa (2)
Ovis aries (2)
Staphylococcus aureus (2)
Aspergillus niger (2)
Mus (2)
Burkholderia cenocepacia H111 (1)
Streptococcus thermophilus (1)
Bartonella henselae (1)
unidentified (1)
Arabidopsis thaliana (1)
Caenorhabditis elegans (1)
Legionella pneumophila str. Paris (1)
Macaca mulatta (1)
Perna viridis (1)
Steinernema carpocapsae (1)
Trichoderma reesei (1)
synthetic construct (1)
Streptomyces sp. F-3 (1)
Plasmodium sp. KYS10 (1)
Suid alphaherpesvirus 1 (1)

Organisms

Mus musculus (8)
Homo sapiens (7)
Oryza sativa Japonica Group (2)
Crotalinae (1)
Legionella pneumophila str. Paris (1)
Steinernema carpocapsae (1)
Macaca nemestrina (1)
Trichoderma reesei (1)
Perna viridis (1)
Caenorhabditis elegans (1)
Ovis aries (1)
Staphylococcus aureus (1)
Rattus norvegicus (1)

Repository

pride (1321)
MassIVE (222)
iProX (121)
jPOST (53)
ENA (33)
PAXDB (32)
geo (29)
biostudies-arrayexpress (24)
PanoramaPublic (15)
MetaboLights (10)
GPMDB (9)
PeptideAtlas (6)
GNPS (4)
BioModels (2)
EGA (1)

Tissue

Cell culture (281)
Epithelial cell (88)
Fibroblast (49)
Macrophage (42)
Brain (37)
Blood plasma (35)
Permanent cell line cell (29)
Saliva (28)
Blood (25)
Cell suspension culture (25)
Liver (25)
Skin (22)
Whole body (22)
Stem cell (21)
Hepatocyte (20)
Plant cell (18)
Bone marrow (17)
Blood serum (17)
Colon (17)
Lung (17)
Heart (15)
Leaf (15)
Primary cell (14)
Endothelial cell of umbilical vein (11)
Blood cell (11)
Extracellular vesicle (10)
B cell (10)
Mesenchymal cell (9)
T cell (9)
Pancreas (9)

Disease

Breast cancer (32)
Disease free (27)
Tuberculosis (16)
Colon cancer (11)
Glioblastoma (10)
Not Available (9)
Melanoma (8)
Wounds and Injuries (8)
Malignant neoplasm of ovary (7)
Prostate adenocarcinoma (7)
Alzheimer's disease (6)
Cardiovascular system disease (6)
Cervix carcinoma (5)
Acute leukemia (5)
Human immunodeficiency virus infectious disease (5)
Diphtheria (4)
Toxoplasmosis (4)
Non-small cell lung carcinoma (4)
Osteoarthritis (4)
Pancreas adenocarcinoma (4)
Retinoblastoma (4)
Type 2 diabetes mellitus (4)
Hyperphosphatemic familial tumoral calcinosis (3)
Pancreatic ductal carcinoma (3)
Pulmonary tuberculosis (3)
Colorectal cancer (3)
Amyotrophic lateral sclerosis (3)
Lymphoma (3)
Malignant pleural mesothelioma (3)
Pancreatic cancer (3)

Technology Type

Mass Spectrometry (1321)
Shotgun proteomics (800)
Bottom-up proteomics (235)
Data-dependent acquisition (121)
Gel-based experiment (107)
Affinity purification coupled with mass spectrometry proteomics (76)
Top-down proteomics (52)
Data-independent acquisition (51)
SWATH MS (36)
Chemical cross-linking coupled with mass spectrometry proteomics (10)
HDMSE (9)
Mass spectrometry (8)
SRM/MRM (7)
MSE (6)
All-ion fragmentation (6)
Mass spectrometry imaging (5)
DiaPASEF (3)
Mass spectrometry assay (2)
Metaproteomics (2)
Proteogenomics (2)
SomaScan affinity proteomics (1)
PAcIFIC (1)
Affinity proteomics (1)
Glycoproteomics (1)
Immunopeptidomics (1)

Instrument Platform

Q Exactive (78)
Orbitrap Fusion Lumos (23)
Orbitrap Fusion (17)
LTQ Orbitrap Velos (14)
Q Exactive Plus (14)
Q Exactive HF-X (12)
Orbitrap Exploris 480 (11)
LTQ Orbitrap (11)
Instrument (9)
Q Exactive HF (9)
TripleTOF 5600 (8)
LTQ FT (6)
LTQ (5)
Orbitrap Eclipse (4)
LTQ Orbitrap Elite (3)
Illumina HiSeq 2500 (2)
TimsTOF Ultra (2)
Q-Exactive (2)
LTQ XL (2)
LTQ Orbitrap XL (2)
TripleTOF 6600 (2)
Orbitrap Fusion ETD (2)
Illumina Genome Analyzer II (1)
NextSeq 500 (1)
7890A GC coupled to a 5975C inert XL MSD, with a 7683 series injector (G2614A) (1)
Autoflex II (1)
Q Exactive Orbitrap HF (1)
Fusion Lumos Tribrid with ETD (1)
QSTAR Elite (1)
LTQ Orbitrap (Thermo Fisher Scientific) (1)

Publication Date

2023 (219)
2025 (215)
2022 (205)
2021 (197)
2024 (183)
2026 (166)
2020 (142)
2019 (112)
2018 (103)
2016 (95)
2017 (86)
2015 (50)
2014 (20)
2013 (12)
2012 (12)
2011 (5)
2010 (4)
2009 (1)

UNIPROT ID/AC

FETUB_HUMAN (18)
CRP_HUMAN (18)
S10A4_HUMAN (18)
S10A8_HUMAN (18)
CAH3_HUMAN (18)
ALBU_HUMAN (18)
ANGT_HUMAN (18)
AACT_HUMAN (18)
C1QR1_HUMAN (18)
K2C4_HUMAN (18)
HBD_HUMAN (18)
EF1G_HUMAN (18)
BIN2_HUMAN (18)
FAAA_HUMAN (18)
GRP75_HUMAN (18)
PGAM1_HUMAN (18)
SCOT1_HUMAN (18)
TBA1C_HUMAN (18)
GANAB_HUMAN (18)
IF4A1_HUMAN (18)
ALDOA_HUMAN (18)
IPO5_HUMAN (18)
HPTR_HUMAN (18)
HEAT1_HUMAN (18)
K1C10_HUMAN (18)
PA2G4_HUMAN (18)
MDHC_HUMAN (18)
PPIB_HUMAN (18)
LYAM1_HUMAN (18)
BIP_HUMAN (18)

CHEBI ID

CHEBI:6426 (2)
CHEBI:16811 (2)
CHEBI:27897 (2)
CHEBI:6650 (2)
CHEBI:25017 (2)
CHEBI:16335 (2)
CHEBI:166925 (1)
CHEBI:195297 (1)
CHEBI:195296 (1)
CHEBI:137945 (1)
CHEBI:195298 (1)
CHEBI:62413 (1)
CHEBI:16189 (1)
CHEBI:25115 (1)
CHEBI:1283 (1)
CHEBI:37691 (1)
CHEBI:63552 (1)
CHEBI:15349 (1)
CHEBI:17459 (1)
CHEBI:58360 (1)
CHEBI:456215 (1)
CHEBI:49182 (1)
CHEBI:15757 (1)
CHEBI:43474 (1)
CHEBI:41425 (1)
CHEBI:24265 (1)
CHEBI:64555 (1)
CHEBI:17502 (1)
CHEBI:28998 (1)
CHEBI:16711 (1)

Metabolite Name

Adenosine (4)
Unidentified (2)
Urocanate (2)
Acetylcarnitine (2)
S-Adenosylmethionine (2)
Carnitine (2)
Phosphoenolpyruvate (2)
Stearic acid (2)
Diethanolamine (2)
Glucose (2)
Phosphocreatine (2)
Triethanolamine (2)
Oleamide (2)
Hexylamine (2)
Heptadecasphinganine (2)
Glycerophosphocholine (2)
Adenine (2)
2-Isopropylmalic acid (2)
Erucamide (2)
Glutathione (2)
Palmitic acid (2)
Oleic acid (2)
Succinate (2)
Pyruvate (2)
Malate (2)
Leucine (2)
Citrate (2)
Arginine (2)
Alanine (2)
Stachyose (2)

First Public Date

2024 (8)
2021 (5)
2025 (4)
2023 (4)
2017 (4)
2026 (3)
2022 (2)
2020 (1)
2015 (1)
2014 (1)

Modelling Approach

Ordinary differential equation model (2)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (34)
The University of Melbourne (8)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (7)
Head of the Curie Institute Mass Spectrometry Platform (6)
Mass Spectrometry Facility, Department of Chemistry and Biochemistry, San Francisco State University, USA (4)
Greehey Children’s Cancer Research Institute, The University of Texas Health Science Center (4)
UMR 7367 CNRS-UL IMoPA Biopôle de l'Université de Lorraine Campus Brabois-Santé 9 avenue de la forêt de Haye 54505 Vandoeuvre-les-Nancy FRANCE (4)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (4)
EDyP (4)
Head of Proteomics (4)
Functional Genomics, University Medicine Greifswald, Germany (3)
Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA (3)
Biological Chemistry Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States (3)
CRUK Beatson Institute (3)
IBCH RAS (3)
Tel Aviv University (3)
University Clinic for Poultry and Fish Medicine, University of Veterinary Medicine, Vienna, Austria (3)
University of Manchester (3)
Proteomics facility, Central Science Laboratory, University of Tasmania (3)
Fondazione Ri.MED (3)
Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences Post Office Box 5003 1432, Ås Norway (3)
University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany (3)
Universität Greifswald Institut für Pharmazie, AG Pharmazeutische Biotechnologie Greifswald, Germany (3)
Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany (3)
Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic (3)
Hannover Medical School Institute for Clinical Biochemistry (OE 4340) Carl-Neuberg-Strasse 1 Building J03, Level 04, Room 1291 (Office), Room 1250 (Lab) 30625 Hannover (2)
Proteomics Mass Spectrometry, University of Tasmania (2)
ICM, Molecular Evolution, Uppsala University (2)
Department Biologie Professur für Mikrobiologie (2)
Forschungszentrum Juelich GmbH ZEA-3 Analytics (2)

IsPrivate

False (2)

Classification

bacteria (2)

Modification

Not available (5)
15.994915 (4)
57.021464 (4)
4x(2)H labeled dimethylated residue (3)
4x(15)N labeled L-arginine (3)
N6-dimethyl-L-lysine (2)
4-tetrahydrothiazine-3-carboxylic acid (2)
0.984016 (1)
71.037114 (1)
42.010565 (1)
4 (1)
2x(15)N labeled L-lysine (1)

Study type

Transcription profiling by array (9)
Proteomic profiling by array (7)
RNA-seq of coding RNA (7)
Cell line - Single-cell sequencing (1)

Release Date

2023 (89)
2022 (88)
2021 (82)
2020 (77)
2015 (66)
2024 (62)
2019 (62)
2025 (56)
2017 (56)
2018 (52)
2016 (48)
2014 (46)
2012 (37)
2013 (36)
2010 (31)
2011 (23)
2009 (19)
2026 (10)
2008 (9)
2007 (5)
2006 (5)
2005 (3)
2004 (1)
2003 (1)
2001 (1)

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Proteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-13 | MTBLS12995 | MetaboLights

Proteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

2025-09-14 | MTBLS12996 | MetaboLights

SILAC proteomic analysis of secreted proteins from PLC cells expressing EV or PRSS35

Since PRSS35 only exhibited tumor suppressive effects in mice, but not in the cultured cells, we speculated that some factors in the microenvironment are affected by PRSS35. To explore this possibility, we performed SILAC proteomic analysis in conjunction with RNA sequencing to identify secreted pro...

ORGANISM(S): Homo sapiens (Human)

2023-02-15 | PXD033579 | Pride

Ev Prss35 Plc Secreted proteins

Comprehensive understanding of identities and antigenicities of surface and secreted proteins in Toxoplasma gondii tachyzoites

PRJNA407885 | ENA

SPECS and proteomics analysis of secreted glycosylated proteins regulated by ADAM12S

We used the secretome protein enrichment with click sugars (SPECS) method to purify the secreted glycosylated proteins and performed quantitative proteomics to identify the secreted proteins that were regulated by ADAM12S.

ORGANISM(S): Homo Sapiens

2022-02-06 | PXD031470 |

Secreted proteins as a fundamental source for biomarker discovery.

Not available

S-EPMC3517109 | biostudies-literature

Toward a better analysis of secreted proteins: the example of the myeloid cells secretome.

Not available

S-EPMC2386146 | biostudies-literature

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues

PRJNA892075 | ENA

Quantitative characterization of the aging intestine secretome reveals novel secreted proteins that act in the extracellular space to regulate lifespan

PRJNA1315043 | ENA