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ProteomicsMouse psd95 coimmunoprecipitation from excitatory or inhibitory neurons and mass spectrometry
We used a psd95-GFP cre dependent KI mouse to label PSD95 with GFP specifically in excitatory (CaMK) or inhibitory (vGAT) neurons. PSD95 was pulled down with a GFP nanobody and the resulting complex was used for massspectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-06-03 | PXD041635 | Pride
Synapse Mouse Psd95 Co-ip 
ProteomicsEndogenous brain ARC complexes
Arc is an activity regulated neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes, role in human disease and cognition. We applied an integrated proteomic and genetic strategy using targeted tagging of a Tandem Affinity Purification (TAP) tag and ...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-19 | PXD007283 | Pride
Complexes Brain Mouse Lc-ms/ms 
ProteomicsTAP-GluN1, PSD95-TAP, WT (control) BNP-LC-MS/MS proteomics
TAP-GluN1 (840 kDa and 1.5 MDa), PSD95-TAP (1.5 MDa) and WT (control; 1.5 MDa) native complexes from Grin1^TAP/TAP, Dlg4^TAP/TAP, and WT mouse forebrain (cortex and hippocampus), respectively. Purified samples were seperated by blue native PAGE. Bands were excised, digested with trypsin. Peptides we...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-20 | PXD000011 | Pride
Native complexes Synapse Nmdar 
UnknownHierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Not available
S-EPMC5601282 | biostudies-literature
UnknownPSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.
Not available
S-EPMC4842999 | biostudies-literature
Genomics
A survey of pairwise epistasis in PSD95 PDZ3
PRJNA642160 | ENA
UnknownEpigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice.
Not available
S-EPMC5841035 | biostudies-literature
UnknownSequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex.
Not available
S-EPMC11581426 | biostudies-literature
UnknownUnveiling the role of PSD95 phosphorylation after traumatic brain injury: insights from phosphoproteomic analysis.
Not available
S-EPMC12312315 | biostudies-literature
UnknownApplication of per-Residue Energy Decomposition to Design Peptide Inhibitors of PSD95 GK Domain.
Not available
S-EPMC9005747 | biostudies-literature
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