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ProteomicsPSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spect...
ORGANISM(S): Homo sapiens (Human) 
2025-01-26 | PXD058954 | Pride
Calcium Ionomycin Pskh1 
ProteomicsPSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spect...
ORGANISM(S): Homo sapiens (Human) 
2025-01-26 | PXD056543 | Pride
Protein kinase  allosteric regulation  calumenin  erc-55  cab-45 
ProteomicsPSKH1 co-immunoprecipitation from human cells and binding partner analysis
PSKH1 co-immunoprecipitation from human cells and binding partner analysis
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055768 | Pride
Co-ip Pskh1 
UnknownPSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup> sensor proteins.
Not available
S-EPMC11873932 | biostudies-literature
UnknownEvolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.
Not available
S-EPMC9988210 | biostudies-literature
UnknownIdentification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.
Not available
S-EPMC3384611 | biostudies-literature
ProteomicsEvolutionary and cellular analysis of the'dark'pseudokinase PSKH2
Pseudokinases, so named because they lack one or more conserved canonical amino acids that define their catalytically-active relatives, have evolved a variety of biological functions in both prokaryotic and eukaryotic organisms. Human PSKH2 is closely related to the canonical kinase PSKH1, which map...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD039306 | Pride
Pseudokinase Pskh2 
ProteomicsPSKH1:UNC119B SDA crosslinking
Recombinant proteins were mixed and then crosslinked by SDA and UV exposure. Complexes were resolved by SDS-PAGE, excised and tryptic peptides identified by MS.
ORGANISM(S): Homo Sapiens (human) 
2025-01-30 | PXD056476 | JPOST Repository
ProteomicsPSKH1:Calmodulin SDA crosslinking
Recombinant proteins were mixed and then crosslinked by SDA and UV exposure. Complexes were resolved by SDS-PAGE, excised and tryptic peptides identified by MS
ORGANISM(S): Homo Sapiens (human) 
2025-01-30 | PXD056468 | JPOST Repository
UnknownRegulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle.
Not available
S-EPMC10970682 | biostudies-literature
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