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ProteomicsTissue Catabolism and Donor-Specific Dexamethasone Response in a Human Osteochondral Model of Post-Traumatic Osteoarthritis
We present an ex vivo human osteochondral model of PTOA to investigate disease effects on catabolism and cellular homeostasis in a multi-tissue system and discover biomarkers for disease progression and drug efficacy.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032213 | Pride
Proteomics Ptoa model Osteochondral Explant culture Dexamethasone 
TranscriptomicsSexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Osteoarthritis (OA) is a disease with sex-dependent prevalence and severity in both human and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (AC...
ORGANISM(S): Mus musculus 
2024-07-17 | GSE271903 | GEO
GenomicsSexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
PRJNA1134075 | ENA
UnknownSynoviocyte-chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects <i>in vitro</i> and <i>in vivo</i>.
Not available
S-EPMC12711863 | biostudies-literature
ProteomicsProteomic Clustering Reveals the Kinetics of Disease Biomarkers in Bovine and Human Models of Post-Traumatic Osteoarthritis
Objectives: In this study, we applied a clustering method to two proteomic data sets from bovine (PRIDE PXD020756) and human models (this repository) of post-traumatic osteoarthritis (PTOA) to distinguish distinct clusters of proteins based on their kinetics of release from cartilage and examined th...
ORGANISM(S): Homo sapiens (Human) 
2021-07-23 | PXD024359 | Pride
Human cartilage Osteoarthritis Explant model 
UnknownGlobal molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.
Not available
S-EPMC5363336 | biostudies-literature
UnknownA Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit.
Not available
S-EPMC11227251 | biostudies-literature
TranscriptomicsTranscriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis
36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Cartilage was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The generated data ...
ORGANISM(S): Sus scrofa 
2017-10-22 | E-MTAB-5879 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis
36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Peri-meniscal synovium was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The ge...
ORGANISM(S): Sus scrofa 
2018-04-21 | E-MTAB-6664 | biostudies-arrayexpress
TranscriptomicsCSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury I
Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the etiology of PTOA and associated functional defici...
ORGANISM(S): Mus musculus 
2025-06-25 | GSE275957 | GEO
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