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TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
ProteomicsNeutrophils from patients with recurring Panton-Valentine Leukocidin-positive Staphylococcus aureus infections are more sensitive to PVL induced NETosis
Panton-Valentine Leukocidin (PVL) is a Staphylococcus aureus toxin that binds to and kills human neutrophils resulting in the formation of neutrophil extracellular traps. A subset of individuals colonized with PVL expressing S. aureus suffer from recurring infections. We found that neutrophils from ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-23 | PXD025702 | Pride
Netosis Nets Mrsa Leukocidin Staphylococcus aureus Pvl 
TranscriptomicsA point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-14394 | biostudies-arrayexpress
TranscriptomicsPanton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA
Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect ba...
ORGANISM(S): Staphylococcus aureus 
2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress
TranscriptomicsA Dysregulated Proinflammatory Status in Preterm School-aged Children with PVL-induced Spastic Cerebral Palsy
Injury occurring during critical periods of development may have long-term effects on inflammatory responses. Periventricular leukomalacia (PVL) is the most common cause of cerebral palsy (CP) in preterm infant. Activated leukocytes are the main source of inflammatory cytokines that give rise to whi...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-17390 | biostudies-arrayexpress
TranscriptomicsComparison of S. aureus PVL-positive and PVL-negative isogenic strains in exponential and stationary phase of growth
The Staphylococcus aureus Panton Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often lethal necrotizing pneumonia. To investigate...
ORGANISM(S): Staphylococcus aureus 
2007-02-13 | GSE6985 | GEO
UnknownOutpatient decolonization after recurrent skin infection with Panton-Valentine leukocidin (PVL)-producing S. aureus-The importance of treatment repetition.
Not available
S-EPMC7173765 | biostudies-literature
UnknownPyoderma outbreak among kindergarten families: Association with a Panton-Valentine leukocidin (PVL)-producing S. aureus strain.
Not available
S-EPMC5736205 | biostudies-literature
UnknownDistinct bacteriophages encoding Panton-Valentine leukocidin (PVL) among international methicillin-resistant Staphylococcus aureus clones harboring PVL.
Not available
S-EPMC3043515 | biostudies-literature
Genomics
MRSA PVL
PRJNA859770 | ENA
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