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TranscriptomicsPanton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA
Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect ba...
ORGANISM(S): Staphylococcus aureus 
2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress
ProteomicsNeutrophils from patients with recurring Panton-Valentine Leukocidin-positive Staphylococcus aureus infections are more sensitive to PVL induced NETosis
Panton-Valentine Leukocidin (PVL) is a Staphylococcus aureus toxin that binds to and kills human neutrophils resulting in the formation of neutrophil extracellular traps. A subset of individuals colonized with PVL expressing S. aureus suffer from recurring infections. We found that neutrophils from ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-23 | PXD025702 | Pride
Netosis Nets Mrsa Leukocidin Staphylococcus aureus Pvl 
TranscriptomicsA point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-14394 | biostudies-arrayexpress
TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
UnknownHost-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.
Not available
S-EPMC7076806 | biostudies-literature
TranscriptomicsPanton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA
Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect bac...
ORGANISM(S): Borreliella burgdorferi Yersinia pestis Chlamydia pneumoniae AR39 Coxiella burnetii RSA 493 Granulibacter bethesdensis Streptococcus pyogenes Staphylococcus epidermidis ATCC 12228 Staphylococcus aureus subsp. aureus MW2 Coxiella burnetii Rickettsia rickettsii Staphylococcus aureus Chlamydia muridarum Staphylococcus epidermidis RP62A Chlamydia caviae GPIC Chlamydia trachomatis Borreliella burgdorferi B31 Chlamydia trachomatis D/UW-3/CX Staphylococcus haemolyticus JCSC1435 
2008-09-12 | GSE8677 | GEO
UnknownTargeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia.
Not available
S-EPMC7478724 | biostudies-literature
UnknownTPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
Not available
S-EPMC10476081 | biostudies-literature
UnknownStaphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc.
Not available
S-EPMC4916384 | biostudies-literature
UnknownStaphylococcus aureus isolates from Eurasian Beavers (Castor fiber) carry a novel phage-borne bicomponent leukocidin related to the Panton-Valentine leukocidin.
Not available
S-EPMC8695587 | biostudies-literature
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