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ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
ProteomicsMining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in numerous essential cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. This ...
ORGANISM(S): Staphylococcus aureus 
2018-10-17 | PXD006483 | Pride
Pyridoxal phosphate Cofactor Vitamin b6 
ProteomicsTailored cofactor traps for the in situ detection of hemithioacetal-forming pyridoxal kinases
Pyridoxal kinases (PLK) are crucial enzymes for the biosynthesis of pyridoxal phosphate, an important cofactor in a plethora of enzymatic reactions. The evolution of these enzymes resulted in different catalytic designs. In addition to the active site, the relevance of a cysteine, embedded within a ...
ORGANISM(S): Escherichia coli Enterococcus faecalis (Streptococcus faecalis) Staphylococcus aureus 
2020-12-23 | PXD021791 | Pride
Pyridoxal E. faecalis Pyridoxal kinase E. coli P. aeruginosa S. aureus Lc-ms/ms 
UnknownChemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.
Not available
S-EPMC3357107 | biostudies-literature
ProteomicsSLC25A38 is Required for Mitochondrial Pyridoxal 5’-Phosphate (PLP) accumulation
Many essential proteins require pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, as a cofactor for activity including enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mammalian PLP-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058312 | Pride
Slc25a38 Mito ip Proliferation defects Lc-ms/ms 
UnknownSLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Not available
S-EPMC11760969 | biostudies-literature
ProteomicsBiochemical and proteomic studies on pyridoxal 5'-phosphate-binding protein (PLPBP)
Structural and proteomic investigations on conserved PLPBP.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015984 | Pride
Prosc Plpbp Pyridoxal 
UnknownBioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.
Not available
S-EPMC3439857 | biostudies-literature
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