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ProteomicsUncovering Global SUMOylation Signaling Networks in a Site-Specific Manner
SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution mass spectrometry, we have studied global SUMOylation in mammalian cells and in a site-specific manner, identifying a total of over 4,300 SUMOylation sites in over 1,600 proteins. Moreov...
ORGANISM(S): Homo sapiens (Human) 
2014-09-04 | PXD001061 | Pride
Sumo-2 Qqtgg Sumo Sumo2 Q87r 
ProteomicsThe SUMO protease SENP6 regulates the constitutive centromere-associated network by group
Project 1: Identification of SUMOylated proteins which are regulated by the SUMO protease SENP6. SENP6 knockdown was performed by two independent shRNAs and SUMOylated proteins were purified from U2OS expressing His10-tagged SUMO2 by means of Ni-NTA pulldown. Purified SUMOylated proteins were identi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD011963 | Pride
Human osteosacrcoma cell line u2os Chromatin Senp6 
ProteomicsSUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage
Small Ubiquitin-like Modifiers play critical roles in the DNA Damage Response (DDR). To increase our understanding of SUMOylation in the mammalian DDR, we employed a quantitative proteomics approach to identify dynamically regulated SUMO-2 conjugates and modification sites upon treatment with the DN...
ORGANISM(S): Homo sapiens (Human) 
2015-03-16 | PXD001810 | Pride
Dna Damage Mms Sumo-2 Sumo Chromatin Repair Site 
ProteomicsA ZNF-nanobody fusion reveals SUMOylation-dependent changes in protein localization
SUMOylation is a post-translational modification regulating protein localization, stability, and activity, with effects varying depending on the identity of the conjugated SUMO protein (SUMO1 or SUMO2/3) and type of SUMOylation (mono-, multi-, or poly-). We previously developed a small 32 amino acid...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD069854 | Pride
ProteomicsA short SUMOylation tag modulates transcription factor activity
This research demonstrates that a short peptide, composed of residues 24-55 of ZNF451, is sufficient to induce SUMOylation of target proteins, both in vitro and in human cells. Increased SUMOylation of the transcription factor p53 via fusion with the ZNF451 peptide inhibits its transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD068083 | Pride
Sumo e3 ligase Small ubiquitin-like modifier (sumo) Transcription factor Sumoylation tag Znf451 Sumoylation P53 
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