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ProteomicsA comprehensive LFQ benchmark dataset to validate data analysis pipelines on modern day acquisition strategies in proteomics
A comprehensive LFQ benchmark dataset to validate data analysis pipelines on modern day acquisition strategies in proteomics using SCIEX TripleTOF5600 and 6600+, Orbitrap QE-HFX, Waters Synapt GS-Si and Synapt XS and Bruker timsTOF Pro.
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) Escherichia coli 
2022-02-14 | PXD028735 | Pride
Swath Dia Benchmark 
ProteomicsA comprehensive LFQ benchmark dataset to validate data analysis pipelines on modern day acquisition strategies in proteomics
A comprehensive LFQ benchmark dataset to validate data analysis pipelines on modern day acquisition strategies in proteomics using SCIEX TripleTOF5600 and 6600+, Orbitrap QE-HFX, Waters Synapt GS-Si and Synapt XS and Bruker timsTOF Pro.
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Candida Albicans (ncbitaxon:5476) Homo Sapiens (ncbitaxon:9606) 
2024-10-23 | MSV000096179 | MassIVE
UnknownQuantitative proteomics reveals Polygonum perfoliatum L. ameliorates hepatic steatosis by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation.
Not available
S-EPMC10076547 | biostudies-literature
MetabolomicsComparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii
Extreme environmental conditions at high altitude, such as hypobaric hypoxia, low temperature, and strong UV radiation, pose a great challenge to the survival of animals. Although the mechanisms of adaptation to high-altitude environments have attracted much attention for native plateau species, the...
2024-01-16 | MTBLS6900 | MetaboLights
ProteomicsMHCI peptidome of HepG2 with ArgRS or SRRM2 knock down
Cells need to sense and respond adequately to environmental stimuli. Metabolites provide information on systemic changes, for example during inflammation. We show that depletion of the amino acid arginine during inflammation reduced nuclear levels of its cognate aminoacyl tRNA synthetase, Arginyl-tR...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD027531 | Pride
Inflammation Mhci Mrna splicing 
ProteomicsMulti-omics of colon tumor progression organoids reveals putative mediators of colorectal cancer metastasis
The development of metastasis severely reduces the life expectancy of patients with colorectal cancer (CRC). Loss of SMAD4 is a key event in late-stage CRC resulting in the progression to metastatic CRC in 10-30% of the cases. However, the biological processes and underlying molecular mechanisms tha...
ORGANISM(S): Homo sapiens (Human) 
2022-12-11 | PXD036441 | Pride
Whole-cell proteomics Secretomics Colon cancer Smad4 Metastasis 
ProteomicsDifferential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly-connected ‘hub’ cells, important for the propagation of intercellular Ca2...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-03-22 | PXD048465 | Pride
Connectivity  cpg methylation  imprinted genes  neuronatin  type 2 diabetes. Beta cell development  identity  heterogeneity  insulin  islet  ca2+ 
ProteomicsPolygonum perfoliatum L. ameliorates NAFLD by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation
We performed a label-free quantitative proteomic profiling to determine the effect of Polygonum perfoliatum L. treated the proteomics profile of liver tissue and identified activated PPARs/CPT1A/CPT2-mediated hepatic fatty acid β oxidation process was significantly altered
ORGANISM(S): Mus Musculus 
2024-02-05 | PXD033219 |
ProteomicsMHCI peptidome of HepG2 with ArgRS or SRRM2 knock down
Cells respond to perturbations like inflammation by sensing changes in metabolite levels. Especially prominent is arginine, which has known connections to the inflammatory response. Here, we found that depletion of arginine during inflammation decreased levels of a nuclear form of arginyl-tRNA synth...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD036232 | Pride
Inflammation Mhci Peptidome 
UnknownMetabolomic Alterations in the Tear Fluids of Patients With Superior Limbic Keratoconjunctivitis.
Not available
S-EPMC8804220 | biostudies-literature
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