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ProteomicsA fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline
Here, we present a standardized, “off-the-shelf” proteomics pipeline working in a single 96-well plate to achieve deep coverage of cellular proteomes with high throughput and scalability. This integrated pipeline streamlining a fully automated sample preparation platform, data independent acquisitio...
ORGANISM(S): Homo sapiens (Human) 
2023-08-22 | PXD029902 | Pride
Dia Ipsc Temporal proteomics Neurodegenerative Single-shot Faims 
ProteomicsProteomics analysis of viral infection in neurons
Endemic viral infections with low pathogenicity are often overlooked due to their mild symptoms, yet they can exert long-term effects on cellular function and contribute to disease pathogenesis. While viral infections have been implicated in neurodegenerative disorders, their impact on the neuronal ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD061286 | Pride
Virus Ipsc-derived neurons 
ProteomicsMaintenance of neuronal TDP-43 expression requires axonal lysosome transport
TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD063206 | Pride
Ipsc neurons tdp43 
ProteomicsAPOE genotype shapes lipid droplet composition and dynamics in human astrocytes
Lipid droplets are dynamic organelles involved in cellular functions ranging from lipid storage regulation to immune modulation. The proteins that localize to the lipid droplet membrane play a critical role in determining these functions. Recent research has highlighted the involvement of glial lipi...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD067161 | Pride
Lipid proteomics Apoe  astrocytes 
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsProteogenomic analysis unveils the expression of cancer associated and specific antigen-derived HLA Class ǀ immunopeptides in melanoma and EGFR mutant lung adenocarcinoma
Immunotherapy has shown great therapeutic potential for cancers with high tumor mutational burden (TMB), but much less promise for cancers with low TMB. One primary approach for adoptive lymphocyte transfer-based immunotherapy is to target the somatic mutated peptide neoantigens and cancer testis (C...
ORGANISM(S): Homo sapiens (Human) 
2021-12-07 | PXD019774 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
UnknownPost-Transcriptional Control of Tropoelastin in Aortic Smooth Muscle Cells Affects Aortic Dissection Onset.
Not available
S-EPMC5881093 | biostudies-literature
UnknownTDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.
Not available
S-EPMC10057836 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownTMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
Not available
S-EPMC10841341 | biostudies-literature
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