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ProteomicsChemical proteomic profiling of protein N-homocysteinylation with a thioester probe
We performed quantitative chemical proteomics to identify more than 800 N-homocysteinylated proteins as well as 304 N-homocysteinylated sites directly from HTL-treated HeLa cells.
ORGANISM(S): Homo Sapiens 
PXD056640 |
UnknownDiscovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity.
Not available
S-EPMC6331161 | biostudies-literature
UnknownNovel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques.
Not available
S-EPMC4722984 | biostudies-literature
TranscriptomicsAb initio identification of transcription start sites (TSSs) in the Rhesus macaque genome by histone modification and RNA-Seq
We addressed the lack of experimentally supported transcript annotations in the Rhesus macaque genome by ab initio identification of the transcription start sites (TSSs). We took advantage of histone H3 lysine 4 trimethylation (H3K4me3)'s ability to mark TSSs and the recently developed ChIP-Seq and ...
ORGANISM(S): Macaca mulatta 
2010-10-18 | E-GEOD-24538 | biostudies-arrayexpress
ProteomicsScreening of targets modified with poly(ADP-ribose) by LC-MSMS
We used mass spectrometry-based proteomic identification to screen poly(ADP-ribosyl)ation (PARylation) targets. Af1521 is a PAR/MAR (mono(ADP-ribose))-binding module with strong affinity towards ADP-ribose. We used Af1521 to perform proteome-wide screening to identify protein that has been modified ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-17 | PXD064443 | Pride
Lc-msms Huvec Poly(adp-ribose) 
ProteomicsMLKL PARylation sites were identified by LC-MSMS
To unravel the molecular mechanism involved in PARP1-mediated MLKL PARylation, the potential PARylation sites were identified in MLKL amino acid sequence by LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2026-10-17 | PXD064394 | Pride
Lc-msms Mlkl Parylation sites 
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
UnknownThe relationship between MAFLD and CVD in a health check-up Chinese population: a prospective cohort study.
Not available
S-EPMC12497973 | biostudies-literature
MetabolomicsEffects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
UnknownAir pollution perception in ten countries during the COVID-19 pandemic.
Not available
S-EPMC8216327 | biostudies-literature
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