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ProteomicsDetermine G6PD/PHGDH deamidation in HepG2 cells with CAD depletion or in cell cycles
We report here that the trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase (CAD) activates the pentose phosphate pathway (PPP) and serine synthesis pathway (SSP) to promote de novo nucleotide synthesis via deamidation. Biochemical analyses show that CAD inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD055217 | Pride
Liver G6pd Phgdh Cad Deamidation 
ProteomicsTear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses
Contact lens-related ocular surface complications occur more often in teenagers and young adults. The purpose of this study was to determine changes in tear proteome of young patients wearing glasses (GL), orthokeratology lenses (OK), and soft contact lenses (SCL). Twenty-two young patients (10-26 y...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD029188 | Pride
Human Soft contact lens Schirmer strip Orthokeratology Tears 
ProteomicsAlterations in tear proteomes of adults with pre-diabetes and type 2 diabetes mellitus but without diabetic retinopathy
This study aims to explore the impact of type 2 diabetes mellitus (T2DM) on tear proteome, specifically investigating whether alterations occur before the development of diabetic retinopathy. Flush tear samples were collected from healthy subjects (n=13), subjects with preDM (n=16) and T2DM (n=18). ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD062366 | Pride
Tear film  type 2 diabetes mellitus  mass spectrometry  proteomics Machine learning. 
UnknownPhotocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.
Not available
S-EPMC12751610 | biostudies-literature
MetabolomicsMetabolic profiling reveals CAD as a central metabolic signaling node
LC MS metabolite profiling and carbon tracing were used to show that the pyrimidine synthesis enzyme CAD regulates glycolysis and branching into pentose phosphate and serine synthesis pathways to support cancer cell proliferation.
2026-02-03 | MTBLS13498 | MetaboLights
ProteomicsProteomics for mouse MCAO/R cortex tissue
Mice were anesthetized with 2% isoflurane (RWD, China), and a midline cervical incision was made to expose the left common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA). The CCA was ligated distally, and two ligatures were placed on the ECA, one at its distal...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD067754 | Pride
Ischemic stroke Proteomics Reperfusion injury Mcao/r Lc-ms/ms 
ProteomicsPhosphoproteomic for mouse MCAO/R cortex tissue
Mice were anesthetized with 2% isoflurane (RWD, China), and a midline cervical incision was made to expose the left common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA). The CCA was ligated distally, and two ligatures were placed on the ECA, one at its distal...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD067636 | Pride
Ischemic stroke Reperfusion injury Mcao/r Lactylation Lc-ms/ms 
UnknownLycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.
Not available
S-EPMC3212826 | biostudies-literature
ProteomicsLactylomics for mouse MCAO/R cortex tissue
Mice were anesthetized with 2% isoflurane (RWD, China), and a midline cervical incision was made to expose the left common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA). The CCA was ligated distally, and two ligatures were placed on the ECA, one at its distal...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD067755 | Pride
Ischemic stroke Reperfusion injury Mcao/r Lactylation Lc-ms/ms 
UnknownC/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.
Not available
S-EPMC12753782 | biostudies-literature
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