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ProteomicsTMT Multiplexing-Based Quantitative Analysis of Pathogenic Th2 Proteomes.
To investigate the regulation of pathogenic Th2 (pTh2) cells and the role of histone deacetylase 1 (HDAC1) in the respective processes, we used a new in vitro protocol for generating pTh2 cells and performed qunatitative mass spectrometry analysis based on TMTpro 16plex multiplexing to analyze prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-20 | PXD042975 | Pride
Tmtpro 16plex Pathogenic th2 cells Mus musculus Th2 cells 
ProteomicsAccelerated age-dependent development of endothelial dysfunction in humanized dyslipidemic mice
In the present work endothelial function in the aorta and femoral artery assessed in vivo by magnetic resonance imaging (MRI) was characterized in male and female 8-, 14-, 22-, 28-, and 40-week-old E3L.CETP and C57BL/6J mice. Vascular nitric oxide (NO), eicosanoids and hydrogen peroxide (H2O2) produ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD029562 | Pride
Qunatitative proteomics Humanized dyslipidemic mice Fasp Endothelial dysfunction Total protein approach 
ProteomicsDissecting ubiquitylation and DNA damage response pathways in the yeast Saccharomyces cerevisiae using a proteome-wide approach
The proper function of DNA damage response pathways (DDR) is essential to protect eukaryotic cells from the accumulation of DNA damage and genome instability, a major cause of cancer and other diseases in humans. Ubiquitylation orchestrates the regulation of DDR events.Blaszczak et al. use quantitat...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-13 | PXD043291 | Pride
Ubiquitylation Imac Nanoluc Qunatitative proteomics Anchor-away Degradation Silac Proteasome Mms Genotoxic stress Ubiquitin Dna damage response 
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