Sort   by:  
 Page size 
UnknownTransgenic LRRK2 (R1441G) rats-a model for Parkinson disease?
Not available
S-EPMC4435452 | biostudies-literature
ProteomicsR1441G but not G201S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
Gain-of kinase function variants in LRRK2 (leucine-rich repeat kinase 2) cause Parkinson’s disease (PD), albeit with incomplete and age-dependent penetrance, offering the prospect of disease-modifying treatment strategies via LRRK2 kinase inhibition. LRRK2 phosphorylates a subgroup of RabGTPases inc...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024898 | Pride
Parkinsosn's disease Prm Lrrk2 Rab-gtpase 
UnknownAffective phenotypes in heterozygous <i>LRRK2</i> R1441G knock-in mice.
Not available
S-EPMC12426193 | biostudies-literature
UnknownLrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.
Not available
S-EPMC2821036 | biostudies-literature
UnknownOral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice.
Not available
S-EPMC7677837 | biostudies-literature
UnknownR1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.
Not available
S-EPMC8357670 | biostudies-literature
UnknownPhosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFNγ and aggravates dopaminergic neurodegeneration.
Not available
S-EPMC10831045 | biostudies-literature
UnknownThe Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons.
Not available
S-EPMC12262611 | biostudies-literature
UnknownA novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Not available
S-EPMC4253647 | biostudies-literature
ProteomicsPhospho-proteome analysis of PBMCs in LRRK2 mutation carriers: expansion & validation of findings of the Barcelona LRRK2 Biorepository
Supported by the Michael J Fox Foundation we established a biorepository of blood cells from G2019S LRRK2-PD patients recruited at the Hospital Clínic de Barcelona (Barcelona). Using this cohort, we performed a phospho-proteomic pilot study by mass spectrometry and identified a differential combinat...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD050944 | Pride
G2019s Phosphoproteome Lrrk2 mutations Parkinson's disease R1441g Pbmcs 
Sort   by:  
 Page size