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ProteomicsQuantitative proteomics study on RA+BDNF induced SHSY5Y differentiation
A detailed quantitative proteomic study upon neuronal differentiation of SHSY5Y by sequential exposure of RA+BDNF
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-22 | MSV000088256 | MassIVE
ProteomicsThe protective effect of docosahexaenoic acid on mitochondria in a SH-SY5Y model of rotenone-induced toxicity
Polyunsaturated fatty acids in particular omega-3 fatty acids, such as docosahexaenoic acid (DHA) are essential nutrients and components of the plasma membrane. They are involved in various processes, among them synaptic development, functionality, integrity and plasticity and are therefore thought ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD049302 | Pride
Dha Proteomics Rotenone Mitochondria Sh-sy5y 
TranscriptomicsDysregulated expression and alternative splicing of genes controlling neuritogenesis and axon guidance revealed by exon-sensitive microarrays in models of neurodegeneration
This SuperSeries is composed of the following subset Series: GSE21298: Profiling wt SOD versus ALS SOD1(G93A) mutant GSE21305: Profiling neuroblastoma SH-SY5Y with Paraquat treatment Mitochondrial dysfunction has been directly or indirectly implicated in the pathogenesis of a number of neurodegener...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21450 | biostudies-arrayexpress
UnknownRA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer's disease mouse models.
Not available
S-EPMC11809180 | biostudies-literature
ProteomicsTemporal proteomic profiling of SH-SY5Y differentiation with retinoic acid using a FAIMS and Real-Time Searching strategy
The SH-SY5Y cell line is often used as a surrogate for neurons in cell-based studies. This cell line is frequently differentiated with all-trans retinoic acid (ATRA) over a 7-day period which confers neuron-like properties to the cells. However, no analysis of proteome remodeling has followed the pr...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD020807 | Pride
Tmtpro Eclipse Atra Sps-ms3 Multi-notch Retinoic acid 
TranscriptomicsGenome-wide analysis of BRCA1 and PALB2 [RA stimulation]
Breast and ovarian cancer susceptibility genes, BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development. While these genes are essential for growth during early developmental programs, inactivation later in adulthood leads to increased growth and formation of tumors, leadi...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-45714 | biostudies-arrayexpress
UnknownImpact of cannabinoids on synapse markers in an SH-SY5Y cell culture model.
Not available
S-EPMC11502758 | biostudies-literature
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
UnknownNeutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro.
Not available
S-EPMC7216824 | biostudies-literature
UnknownNeuroprotective activity of green synthesized silver nanoparticles against methamphetamine-induced cell death in human neuroblastoma SH-SY5Y cells.
Not available
S-EPMC10363122 | biostudies-literature
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